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首页> 外文期刊>Breast cancer research and treatment. >Systemic Effects of Surgery: Quantitative Analysis of Circulating Basic Fibroblast Growth Factor (bFGF), Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor Beta (TGF-beta) in Patients with Breast Cancer Who Underwent Limited or
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Systemic Effects of Surgery: Quantitative Analysis of Circulating Basic Fibroblast Growth Factor (bFGF), Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor Beta (TGF-beta) in Patients with Breast Cancer Who Underwent Limited or

机译：手术的全身效果：定量分析有限度或部分乳腺癌患者中循环碱性成纤维细胞生长因子（bFGF），血管内皮生长因子（VEGF）和转化生长因子β（TGF-β）的定量分析

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Background. To assess if feature, extent and duration of surgery could influence levels of systemic proangiogenic cytokines vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF-beta). Patients and methods. We collected blood samples from 82 consecutive breast cancer patients who underwent various types of surgery, classified according to the magnitude of tissue injury in: minimal (quadrantectomy), moderate (mastectomy without reconstruction), and heavy [mastectomy followed by reconstruction with transversus recto-abdominal muscle cutaneous flap (TRAM)]. Samples were collected one day before surgery (D(-1)), at the end of surgical tumor removal (D(0)), and on 1st (D(+1)), 2nd (D(+2)) and 5th (D(+5)) day after surgery. Serum VEGF, bFGF and TGF-beta levels were measured by the enzyme immunoassay method. Results. On average a continuous decrease was observed for all growth factors from the day before operation to the 5th day after operation. On day (D(+5)) an increase was observed for patients who underwent extended respect to moderate surgery. These differences were found statistically significant for bFGF and VEGF (p = 0.05 and p = 0.025 respectively). A statistically different trend for type of operation was observed also for TGF-beta at 24-48 h: a minor reduction, compared to time of operation, was observed for minimal surgery, an intermediate reduction for moderate surgery and a higher decrease for extended surgery. Conclusions. Angiogenic cytokines perioperative levels could be increased on 5th day (D(+5)) by extent of surgery and should induce perioperative stimulation of residual cancer cells. A better understanding of the time interval during which the sequelae of events in wound healing occur may be the basis for defining new therapeutic strategies that can interfere with tumor outgrowth sparing wound healing processes.
机译：背景。为了评估手术的特征，程度和持续时间是否会影响全身性促血管生成细胞因子，血管内皮生长因子（VEGF），碱性成纤维细胞生长因子（bFGF）和转化生长因子beta（TGF-beta）的水平。患者和方法。我们从82例接受了各种手术的连续乳腺癌患者中收集了血液样本，根据组织损伤的程度分为以下几种：最小（象限切除术），中度（不进行重建术的乳房切除术）和重度[乳房切除术，然后经直肠直肠切除术腹肌皮瓣（TRAM）]。手术前一天（D（-1）），手术肿瘤切除结束（D（0））以及第一天（D（+1）），第二天（D（+2））和第五天收集样品手术后（D（+5））天。通过酶免疫法测定血清VEGF，bFGF和TGF-β水平。结果。从手术前一天到手术后第5天，平均观察到所有生长因子的持续下降。在第（D（+5）天），接受了中等手术扩展治疗的患者增加了。发现这些差异对bFGF和VEGF具有统计学意义（分别为p = 0.05和p = 0.025）。 TGF-beta在24-48小时也观察到了手术类型的统计学差异：与手术时间相比，最小手术减少了，中等手术减少了，中等手术减少了。结论血管生成细胞因子的围手术期水平可在第5天（D（+5））随手术程度而增加，并应诱导围手术期对残余癌细胞的刺激。更好地了解伤口愈合事件后遗症发生的时间间隔可能是定义新的治疗策略的基础，这些策略可以干扰保留肿瘤愈合过程的肿瘤生长。

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