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首页> 外文期刊>Breast cancer research and treatment. >Is family history related to preventive health behaviors and medical management in breast cancer patients?
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Is family history related to preventive health behaviors and medical management in breast cancer patients?

机译：家族史与乳腺癌患者的预防健康行为和医疗管理有关吗？

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INTRODUCTION: Women diagnosed with breast cancer who also have a family history of the disease are at increased risk of developing additional primary breast or ovarian cancers. We investigated whether a relationship exists between family history and health behaviors in a cross-sectional study of breast cancer survivors. METHODS: Participants in the Women's Healthy Eating and Living (WHEL) Study (a randomized trial designed to test the effect of a plant-based diet on breast cancer recurrence) completed baseline questionnaires about their family history and health behaviors. Medical records and self-reports provided treatment data. Participants were defined as having a family history (FH+) if they met specific family history criteria (n=195), and were compared with women having no family history (FH-) of breast cancer (n=1736). RESULTS: The mean age of breast cancer diagnosis was 51.2 years for both groups, but FH+ women were more likely to be diagnosed before age 40. FH+ and FH- women had similar dietary patterns, alcohol intake, exercise patterns, body mass index and smoking histories. However, FH+ women were more likely to have undergone prophylactic contralateral mastectomy (OR=3.6, 95% CI=2.2 - 6.2) and bilateral oophorectomy (OR=1.6; 95% CI=1.0 - 2.3) following diagnosis, adjusted for age and time since diagnosis. The FH+ and FH- groups had similar patterns of use of anti-estrogen medications and frequency of medical follow-up. CONCLUSIONS: Breast cancer survivors with a strong family history of breast cancer are more likely to undergo surgical preventive measures to reduce their risk of additional cancer, but do not report undertaking more preventive lifestyle behaviors compared to breast cancer survivors without a family history.
机译：简介：被诊断患有乳腺癌且也有家族病史的女性患上其他原发性乳腺癌或卵巢癌的风险增加。在一项针对乳腺癌幸存者的横断面研究中，我们调查了家族史和健康行为之间是否存在关系。方法：妇女健康饮食和生活（WHEL）研究（一项旨在测试植物性饮食对乳腺癌复发的影响的随机试验）参与者完成了有关其家族史和健康行为的基线调查表。医疗记录和自我报告提供了治疗数据。如果参与者符合特定的家族史标准（n = 195），则被定义为有家族史（FH +），并与没有乳腺癌家族史（FH-）的女性进行比较（n = 1736）。结果：两组的乳腺癌平均诊断年龄均为51.2岁，但FH +妇女更有可能在40岁之前被诊断出。FH +和FH-妇女的饮食习惯，饮酒，运动方式，体重指数和吸烟情况相似历史。然而，根据年龄和时间调整后，FH +妇女在诊断后更可能接受预防性对侧乳房切除术（OR = 3.6，95％CI = 2.2-6.2）和双侧卵巢切除术（OR = 1.6; 95％CI = 1.0-2.3）。自诊断以来。 FH +和FH-组的抗雌激素药物使用方式和医疗随访频率相似。结论：具有家族史的乳腺癌幸存者比没有家族史的乳腺癌幸存者更有可能采取外科手术预防措施以降低罹患额外癌症的风险，但没有报告采取更多的预防性生活方式。

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