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首页> 外文期刊>Annals of Saudi medicine >Defecation of a 'colon cast' as a rare presentation of acute graft-versus-host disease.
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Defecation of a 'colon cast' as a rare presentation of acute graft-versus-host disease.

机译：排便“冒号”是急性移植物抗宿主病的罕见表现。

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摘要

Diffuse involvement of the gastrointestinal tract by graft versus host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplant (HSCT). Gastrointestinal GVHD usually presents 3 or more weeks after HSCT and is characterized by profuse diarrhea, anorexia, nausea, vomiting, abdominal pain and gastrointestinal bleeding. We report a case of a 23-year-old male who had undergone allogeneic HSCT and presented with bloody diarrhea on the 90th day post-HSCT. On the fourth day of admission, the patient passed per rectum a 27-cm long pinkish colored fleshy material recognized as a "colon cast". Sigmoidoscopy showed a congested and erythematous rectum with the remaining portion of the colon cast the rectal wall was suggestive of grade IV GVHD. The patient was treated with methylprednisolone, cyclosporin and mycophenolate mofetil, with a partial response (diarrhea and abdominal pain improved), but then he developed multiple other medical complications and died after 3 months.
机译：异体造血干细胞移植（HSCT）的常见并发症是移植物与宿主疾病（GVHD）引起的胃肠道弥漫性累及。胃肠道GVHD通常在HSCT后3周或更长时间出现，其特征是大量腹泻，厌食，恶心，呕吐，腹痛和胃肠道出血。我们报告了一例23岁的男性，该男性经历了同种异体HSCT，并在HSCT后第90天出现了血性腹泻。在入院的第四天，患者每个直肠通过了27厘米长的粉红色肉质物质，被认为是“冒号”。乙状结肠镜检查显示直肠充血和红斑，结肠的其余部分铸成直肠壁，提示IV级GVHD。该患者接受甲基强的松龙，环孢菌素和霉酚酸酯的治疗，部分缓解（腹泻和腹痛得到改善），但随后出现其他多种医学并发症，并在3个月后死亡。

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