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首页> 外文期刊>Aviation, space, and environmental medicine. >Mouse plantar flexor muscle size and strength after inactivity and training.
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Mouse plantar flexor muscle size and strength after inactivity and training.

机译：不运动和训练后的小鼠plant屈肌大小和强度。

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INTRODUCTION: Losses in muscle mass and strength may affect an astronaut's safety; therefore, it is of utmost importance to optimize countermeasures to minimize atrophy and strength loss during spaceflight. The main purpose of this study was to determine if high force eccentric or isometric contractions performed by the plantar flexor group during hind limb suspension would preserve muscle mass and strength. METHODS: Plantar flexor muscles of mice were trained with either eccentric or isometric contractions every other day during a 10-d hind limb suspension period. Pre- and post-suspension stimulation frequency- and angular velocity-dependent measurements of torque of the plantar flexors, soleus twitch (Pt) and tetanic (Po) force, bodyweight, and muscle wet weight measurements were made. RESULTS: The 19 and 26% losses in gastrocnemius and soleus muscle wet weights, respectively, were not attenuated with eccentric or isometric contractions. Neither eccentric nor isometric contractions attenuated the soleus muscle's 30% isometric force loss after hind limb suspension. Despite losses in muscle mass, there was no decrease in the force produced by the plantar flexor muscle group after hind limb suspension. DISCUSSION: Hind limb suspension decreased both gastrocnemius and soleus mass, and in vitro soleus force production. However, in vivo force production of the plantar flexor muscle group did not decrease, which may be explained by a shift in the isometric torque: ankle angle relationship. The use of eccentric or isometric contractions as a countermeasure to offset muscle mass and strength requires further investigation as neither was capable of maintaining soleus muscle force production, or gastrocnemius and soleus muscle mass during hind limb suspension.
机译：简介：肌肉质量和力量的损失可能会影响宇航员的安全;因此，最优化对策以最小化太空飞行中的萎缩和强度损失至关重要。这项研究的主要目的是确定在后肢悬吊过程中by屈肌群进行的强力离心或等距收缩是否能保留肌肉质量和力量。方法：在后肢悬吊10天的过程中，每隔一天对小鼠的flex屈肌进行偏心或等距收缩训练。进行悬吊前后刺激频率和角速度相关的足底屈肌扭矩，比目鱼肌抽搐（Pt）和强直肌（Po）力，体重和肌肉湿重的测量。结果：腓肠肌和比目鱼肌湿重分别减少了19％和26％，但未因偏心或等距收缩而减弱。偏心收缩和等距收缩都不能减弱后肢悬吊后比目鱼肌等轴测力的30％损失。尽管肌肉质量下降，但后肢悬吊后the屈肌群产生的力并未降低。讨论：后肢悬吊可降低腓肠肌和比目鱼肌的质量，并降低体外比目鱼肌的产生。然而，足底屈肌群的体内力产生并未减少，这可以通过等距扭矩：踝角关系的偏移来解释。使用偏心或等距收缩来抵消肌肉质量和力量的对策需要进一步研究，因为在后肢悬吊过程中，均无法维持比目鱼肌力量的产生，腓肠肌和比目鱼肌的质量。

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