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首页> 外文期刊>Autism research: official journal of the International Society for Autism Research >Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder
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Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder

机译：自闭症谱系障碍的小男孩子集中增加的表面积，但没有增加皮质的厚度

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The Autism Phenome Project is the largest, single site, longitudinal magnetic resonance imaging (MRI) study of young children with autism spectrum disorder (ASD). Previous analyses from this cohort have shown that the children with autism have a total brain volume at time 1 (approximate to 3 years of age) that is 6% larger than typically developing (TD) children. This finding is driven primarily by 15% of the boys with ASD that have disproportionate megalencephaly (ASD-DM) or brain size that is 1.5 standard deviations above what would be expected for the child's height. In the current study, cerebral cortical grey matter volume, thickness, and surface area were assayed from MRI scans of 112, 3-year-old boys with ASD and 50 age-matched TD boys. The boys with ASD-DM (n=17) were analyzed separately from the boys with normal brain size (ASD-N, n=95). Previous studies of cortical thickness and surface area for ASD children in this age range have come to diametrically different conclusions concerning the significance of cortical thickness vs. surface area. Current analyses indicate that cortical thickness was comparable across the ASD and TD groups. However, surface area was significantly greater in the ASD group compared to the TD group. This result was driven largely by the children with ASD-DM. Even in the ASD-DM group, not all cortical regions demonstrated increased surface area. These results provide strong evidence that the early cortical overgrowth associated with ASD is due primarily to increased surface area and not to increased cortical thickness. Autism Res2016, 9: 232-248. (c) 2015 International Society for Autism Research, Wiley Periodicals, Inc.
机译：自闭症现象项目是对自闭症谱系障碍（ASD）的幼儿进行的最大的单点纵向磁共振成像（MRI）研究。该队列的先前分析表明，自闭症儿童在第1时（约3岁）的大脑总容量比正常发育（TD）儿童大6％。这一发现主要是由15％的ASD男孩的超大头畸形（ASD-DM）或大脑尺寸超出预期的儿童身高1.5个标准差所致。在本研究中，通过对112名3岁ASD男孩和50名年龄相匹配的TD男孩进行MRI扫描，分析了大脑皮层灰质的体积，厚度和表面积。对具有ASD-DM（n = 17）的男孩和具有正常脑尺寸（ASD-N，n = 95）的男孩分别进行了分析。先前针对这一年龄段的ASD儿童的皮质厚度和表面积的研究得出了截然不同的结论，即皮质厚度对表面积的重要性。目前的分析表明，在ASD和TD组中，皮质厚度是可比的。但是，与TD组相比，ASD组的表面积明显更大。这一结果主要是由患有ASD-DM的儿童推动的。即使在ASD-DM组中，并非所有皮质区域都显示出增加的表面积。这些结果提供了有力的证据，表明与ASD相关的早期皮质过度生长主要是由于表面积增加而不是皮质厚度增加所致。自闭症研究2016，9：232-248。 （c）2015年国际自闭症研究协会，Wiley Periodicals，Inc.。

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