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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >Effect of platelet-rich plasma mixed with a polymeric bone filling material on sinus floor augmentation in rabbits
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Effect of platelet-rich plasma mixed with a polymeric bone filling material on sinus floor augmentation in rabbits

机译：富血小板血浆与聚合物骨填充材料混合对家兔窦底增强的影响

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摘要

Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy but an ideal material to increase the bone volume for dental implantation is still needed. The present study evaluated the effect of a newly developed polymeric bone-filling powder (formed from acrylic acid and N-isopropylacrylamide, ANa) mixed with platelet-rich plasma (PRP) for bone generation in a rabbit model of sinus augmentation. A total of 12 New Zealand White rabbits were randomly divided into three groups based on filling material. All animals underwent a bilateral maxillary sinus augmentation. PRP was prepared using an automatic separation system to obtain a high platelet concentration. ANa powder was individually mixed with phosphate-buffered saline (PBS) or PRP for sinus floor elevation. The left maxillary sinus received the ANa/PBS filling, whereas the right maxillary sinus received a mixture of ANa/PRP gel. Equal volumes of filling material were inserted in each maxillary sinus. Thus, defects with no implantation served as controls. Animals were sacrificed at 4 and 12 weeks, and then all specimens were harvested for micro-computed tomography (micro-CT) and histological analysis. On micro-CT evaluation, ANa/PRP significantly increased the bone volume in maxillary sinus augmentation relative to the negative control and ANa/PBS after 12 weeks. New bone areas with osteocytes and osteon formation were found in all three groups at 12 weeks post-implantation. This study confirms that ANa mixed with PRP can effectively increase the bone volume in the sinus cavity. This benefit for sinus augmentation may increase the success of dental implantation because of the formation of a thin layer of alveolar bone.
机译：鼻窦增厚是严重牙槽萎缩患者的常用方法，但仍需要一种理想的材料来增加牙齿植入的骨量。本研究评估了一种新开发的聚合物骨填充粉末（由丙烯酸和N-异丙基丙烯酰胺，ANa形成）与富含血小板的血浆（PRP）混合，在兔窦增大模型中对骨生成的影响。根据填充材料，将总共12只新西兰白兔随机分为三组。所有动物都进行双侧上颌窦增大。使用自动分离系统制备PRP，以获得高血小板浓度。将ANa粉末分别与磷酸盐缓冲盐水（PBS）或PRP混合以提高窦底高度。左上颌窦接受ANa / PBS填充，而右上颌窦接受ANa / PRP凝胶混合物。等体积的填充材料插入每个上颌窦。因此，将没有植入的缺陷用作对照。在第4周和第12周处死动物，然后收集所有标本用于显微计算机断层扫描（micro-CT）和组织学分析。通过微CT评估，相对于阴性对照和ANa / PBS，在12周后，ANa / PRP显着增加了上颌窦增大中的骨量。植入后12周，所有三个组均发现了具有骨细胞和骨形成的新骨区域。这项研究证实，将ANa与PRP混合可以有效增加窦腔中的骨量。由于形成了一个薄薄的牙槽骨层，所以这种增加窦性的好处可以增加牙科植入的成功率。

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