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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >Meshed scaffolds made of α, α'-bis(2-Hydroxyethyl Methacrylate) Poly(ethylene glycol) through 3D stereolithography
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Meshed scaffolds made of α, α'-bis(2-Hydroxyethyl Methacrylate) Poly(ethylene glycol) through 3D stereolithography

机译：通过3D立体光刻法，由α，α'-双（2-羟乙基甲基丙烯酸甲酯）聚乙二醇制成的网状支架

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Recent development of tissue engineering scaffolds that mimic anatomical structures exhibits a tendency to use rapid prototyping technology, because it can be applied to precisely manufacture the designed objects from the computer-generated model. Among all of rapid prototyping approaches, combining with lithography is characterized with a high throughput of fabrication, especially for the fabrication of polymeric scaffolds. In this study, the aims were to: (1) synthesize the 2-hydroxyethyl methacrylate (HEMA)-capped poly(ethylene glycol) (PEG), which served as the cross-linker of the continuous phase of a poly(lactide-co-glycolide) (PLGA) scaffold and (2) fabricate the composite scaffolds through stereolithography. The synthetic process of the cross-linker was traced, and the end-point of the process was found to lie in 3 to 4 h depending on the molecular weight of the PEG used. The chemical structure of the cross-linker was found to be linear and symmetric to PEG and with a 1:2 molar ratio of PEG and HEMA. It was anticipated to form an interpenetrating network upon irradiating under UV light with PLGA serving as the main body of the scaffold. PEG1000-HEMA had better biocompatibility than those with shorter PEG chains. Scaffolds with two structural variants, square and hexagonal pores, designed by computer were demonstrated. It may further combine medical images to reconstruct tissues and organs for regenerative medicine.
机译：模仿解剖结构的组织工程支架的最新发展显示出使用快速原型技术的趋势，因为它可以用于根据计算机生成的模型精确制造设计的对象。在所有快速原型制作方法中，与光刻相结合的特征是具有高制造通量，特别是对于聚合物支架的制造。在这项研究中，目标是：（1）合成甲基丙烯酸2-羟乙酯（HEMA）封端的聚乙二醇（PEG），该聚乙二醇用作聚丙交酯共聚物连续相的交联剂。 -乙交酯（PLGA）支架，以及（2）通过立体平版印刷术制造复合支架。追踪了交联剂的合成过程，发现该过程的终点在3-4小时内，具体取决于所用PEG的分子量。发现交联剂的化学结构与PEG线性且对称，并且PEG与HEMA的摩尔比为1：2。预期在以PLGA作为支架的主体在UV光下照射时会形成互穿网络。 PEG1000-HEMA的生物相容性优于PEG链较短的生物相容性。演示了由计算机设计的具有两种结构变体的方孔和六角孔的支架。它可以进一步组合医学图像以重建用于再生医学的组织和器官。

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