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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >A NOVEL FOAMY COLLAGEN AS A DURAL SUBSTITUTE
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A NOVEL FOAMY COLLAGEN AS A DURAL SUBSTITUTE

机译：一种新型的泡沫胶原蛋白，可作为替代品

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摘要

This study developed an innovative foamy collagen dural substitute. The foamy collagen was prepared by mixing collagen hydrogel and high-pressure oxygen in a stainless steel bottle as a container. A foamy collagen with 101 ± 43 μm in pore size and 50.5 ± 5.1% in porosity formed after release from the container. In the results of the in vitro degradation experiment, foamy collagen degraded slower than the commercially available DuraGen treated with 5 units/mL of collagenase solution. DuraGen degraded completely within three hours and foamy collagen had 39.2% (mean) of its original mass remaining 24 h after immersing in collagenase solution. The oxygen bubble structure was immobilized by the collagen fibrillogenesis and remained intact 3 and 7 days after subcutaneous implantation of the foamy collagen in rats, without any escape or merge of the oxygen bubbles. Fibrous tissue proliferated along the porous structure from the edge of the foamy collagen according to the histology analysis of subcutaneous implantation experiment in rats. The results of in vivo rabbit duraplasty experiment showed that the regenerated dura in foamy collagen group was thicker than that in DuraGen group, and was comparable to the native dura mater, without causing any adverse effects, such as intracranial pressure increase or cerebrospinal fluid leakage.
机译：这项研究开发了一种创新的泡沫状胶原硬脑膜替代品。通过将胶原水凝胶和高压氧气在作为容器的不锈钢瓶中混合来制备泡沫胶原。从容器中释放出来的泡沫状胶原蛋白的孔径为101±43μm，孔隙率为50.5±5.1％。在体外降解实验的结果中，泡沫胶原蛋白的降解速度比以5单位/ mL的胶原酶溶液处理的市售DuraGen慢。 DuraGen在3小时内完全降解，泡沫胶原蛋白浸入胶原酶溶液24小时后，其原始质量的39.2％（平均值）保留下来。氧气泡结构通过胶原纤维原纤维形成而固定，并且在大鼠中泡沫状胶原的皮下植入后3天和7天保持完整，没有氧气泡的任何逸出或合并。根据大鼠皮下植入实验的组织学分析，纤维组织从泡沫胶原的边缘沿多孔结构增殖。体内兔硬脑膜成形术的结果表明，泡沫胶原蛋白组的再生硬脑膜比DuraGen组的硬脑膜厚，并且与天然硬脑膜相当，不会引起任何颅内压升高或脑脊液渗漏等不良影响。

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