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首页> 外文期刊>Biomedical Engineering: Applications, Basis and Communications >THE FURTHER CHARACTERIZATION OF THE SPECIFICALLY BINDING PEPTIDE TO HEPATOCELLULAR CARCINOMA
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THE FURTHER CHARACTERIZATION OF THE SPECIFICALLY BINDING PEPTIDE TO HEPATOCELLULAR CARCINOMA

机译：特定结合肽对肝细胞癌的进一步表征

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摘要

Previously, we reported a novel 12-mer peptide binding to hepatocellular carcinoma (HCC) cells specifically and sensitively, and it was screened by using a phage displayed peptide library. To identify the potential of this peptide to be used to the early diagnosis and drug delivery of HCC clinic, the synthesized peptide probe was further characterized by using the assays of cell immunofluorescence and tissue chip. The results of cultured cell immunofluorescence assay show that the peptide probe binds to HCC cells with satisfactory specificity and sensitivity. The results of tissue chip show that the peptide probe can bind to the most common types of HCC tissues, especially to the HCC tissues differentiated at grade II. All further characterized results indicate that this peptide is of the great potential to be used as a HCC targeting candidate for the early molecular imaging diagnosis and targeting nanoparticle or drug delivery in HCC clinic practice.
机译：以前，我们报道了一种新型12-mer肽特异性和灵敏地与肝细胞癌（HCC）细胞结合，并通过使用噬菌体展示的肽库进行筛选。为了鉴定该肽用于肝癌临床早期诊断和给药的潜力，通过使用细胞免疫荧光和组织芯片的分析进一步表征了合成的肽探针。培养的细胞免疫荧光分析的结果表明，该肽探针以令人满意的特异性和敏感性与HCC细胞结合。组织芯片的结果表明，该肽探针可以结合最常见的HCC组织类型，尤其是II级分化的HCC组织。所有进一步表征的结果表明，该肽具有巨大的潜力，可用作HCC临床实践中早期分子成像诊断和靶向纳米颗粒或药物递送的HCC靶向候选物。

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