Multichannel planar microelectrode array for somatic mapping in rats

Shaw F.-Z.; Yang T.-F.; Huang C.-C.; Yeh K.-H.; Chang T.-C.; Leu F.-J.

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Multichannel planar microelectrode array for somatic mapping in rats

机译：用于大鼠体细胞定位的多通道平面微电极阵列

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Planar electrode array is an important tool to evaluate perceptual or cognitive functions of the cortex and prosthetic applications. Many construction methods have been developed. To maximize the usefulness of an array electrode, a low-cost, precise, and flexible microelectrode array with low man power and short construction duration is crucial. In this study, we introduced an 8 × 8 microelectrode array on a flexible polyimide film through microelectronics fabrication. The array dimension was capable of covering the primary somatosensory cortex of a rat. The microelectrode array was insulated with biocompatible Parylene-C except of microelectrode tip. Each electrode tip was 66 μm height and separated with 0.5 mm to refine a detail somatic sensory processing. In pentobarbital anesthetized rats, stable spontaneous brain activity was successfully recorded through the electrode array. In addition, positive peaks of somatosensory evoked potentials (SEPs) elicited by stimulating rat's whisker pad, forepaw, hindpaw, and tail were obviously and consistently recorded. Latencies of SEPs increased as caudal part of the body was stimulated. The SEPs from stimulation of 4 body parts revealed different spatiotemporal patterns, which indicated a somatotopic organization of the rat. Our results demonstrated the superiority of the planar microelectrode array on the application of simultaneous recording and analysis of the brain activity in rats.

机译：平面电极阵列是评估皮质和假体应用的知觉或认知功能的重要工具。已经开发了许多构造方法。为了最大化阵列电极的实用性，至关重要的是，低成本，精确且灵活的微电极阵列，其具有低人力和短施工时间。在这项研究中，我们通过微电子制造在柔性聚酰亚胺薄膜上引入了8×8微电极阵列。阵列尺寸能够覆盖大鼠的主要体感皮层。微电极阵列用生物相容的Parylene-C绝缘，除了微电极尖端。每个电极头的高度为66μm，并相隔0.5 mm，以细化体细胞感觉的详细过程。在戊巴比妥麻醉的大鼠中，通过电极阵列成功记录了稳定的自发脑活动。此外，明显且一致地记录了通过刺激大鼠的晶须垫，前爪，后爪和尾巴引起的体感诱发电位（SEP）的正峰。 SEPs的潜伏期随着身体尾部的刺激而增加。刺激4个身体部位产生的SEP显示出不同的时空模式，这表明该大鼠具有躯体组织。我们的结果证明了平面微电极阵列在同时记录和分析大鼠脑活动方面的优越性。

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《Biomedical Engineering: Applications, Basis and Communications》 |2011年第6期|共8页
作者
Shaw F.-Z.; Yang T.-F.; Huang C.-C.; Yeh K.-H.; Chang T.-C.; Leu F.-J.;
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原文格式 PDF
正文语种 eng
中图分类医用一般科学;
关键词
Array; MEMS; Microelectrode; Planar; Somatotopic map;

机译：阵列;MEMS;微电极;平面;体位图;

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1. Multichannel planar microelectrode array for somatic mapping in rats [J] . Shaw F.-Z., Yang T.-F., Huang C.-C., Biomedical Engineering: Applications, Basis and Communications . 2011,第6期

机译：用于大鼠体细胞定位的多通道平面微电极阵列
2. A low noise multichannel integrated circuit for recording neuronal signals using microelectrode arrays [J] . Dabrowski W., Grybos P., Litke AM. Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices . 2004,第7期

机译：用于使用微电极阵列记录神经元信号的低噪声多通道集成电路
3. Skeletal Myotube Integration with Planar Microelectrode Arrays In Vitro for Spatially Selective Recording and Stimulation: A Comparison of Neuronal and Myotube Extracellular Action Potentials [J] . Christopher G. Langhammer, Melinda K. Kutzing, Vincent Luo Biotechnology Progress . 2011,第3期

机译：骨骼肌管与平面微电极阵列的体外集成的空间选择性记录和刺激：神经元和肌管细胞外动作电位的比较。
4. Multichannel Planar Microelectrode Platform for Recording Extracellular Field Potentials [C] . J.C. Franco, M.A. Portela, H. Andrade-Caicedo Latin American Congress on Biomedical Engineering . 2017

机译：用于记录细胞外场电位的多通道平面微电极平台
5. In silico model of in vitro dissociated cortical networks on planar microelectrode arrays. [D] . Dockendorf, Karl Paul. 2007

机译：平面微电极阵列上体外离解皮层网络的计算机模型。
6. Skeletal myotube integration with planar microelectrode arrays in vitro for spatially selective recording and stimulation: A comparison of neuronal and myotube extracellular action potentials [O] . Christopher G. Langhammer, Melinda K. Kutzing, Vincent Luo, -1

机译：与平面微电极阵列的骨骼肌室集成用于空间选择性记录和刺激：神经元和肌室细胞外动作电位的比较
7. How to achieve sub-cellular-level spatial resolution and sub-spike-level temporal resolution at same time is still a technical challenge in neural mapping while both information are critically important to advance neural science. Here, we present penetrating arrays consisted of single-neuron level transparent microelectrodes with low impedance coating which could realize the high spatial and temporal resolution at the same time. These 32-channel transparent penetrating electrodes with record-small site area, 225 µm², have a low impedance of ~ 149 kΩ at 1 kHz, an adequate charge injection limit of ± 0.76 mC/cm2, and up to 100 yield. Mechanical bending test result show robust mechanism up to 1000 bending cycles. After a temporary stiffen with polyethylene glycol, this electrode achieved great insertion result without any buckling or deformation. Together these results establish a novel neurotechnology - penetrating arrays of transparent, flexible bilayernanomeshMicroelectrodes which possess great potential for brain research [O] . Zhan Shi -1

机译：如何在同一时间实现子蜂窝级空间分辨率和子峰值级时间分辨率在神经映射中仍然是技术挑战，而两个信息对于推进神经科学来说都很重要。这里，我们提出穿透阵列由单神经元级透明微电极组成，具有低阻抗涂层，其可以同时实现高空间和时间分辨率。这些32通道透明穿透电极具有记录小的部位面积，225μm²的低阻抗在1 kHz的〜149kΩ的低阻抗，充足的电荷注入极限为±0.76mc / cm2，率高达100％。机械弯曲试验结果显示高达1000个弯曲循环的强大机制。在用聚乙二醇进行临时变硬后，该电极实现了很大的插入结果，而无需任何屈曲或变形。这些结果共同建立了一种新型神经技术 - 穿透透明，灵活的双层圆形脉冲阵列，其具有巨大的大脑研究潜力

Multichannel planar microelectrode array for somatic mapping in rats

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