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首页> 外文期刊>Annual Review of Pharmacology and Toxicology >Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved?
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Biochemical mechanism of nitroglycerin action and tolerance: is this old mystery solved?

机译：硝酸甘油作用和耐受性的生化机制：这个古老的谜团被解决了吗？

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Organic nitrates such as nitroglycerin (NTG) have been used as potent vasodilators in medicine for more than a century, but their biochemical mechanisms of action, particularly in relation to tolerance development, are still incompletely defined. Numerous candidate enzymes for NTG metabolism, as well as a multiplicity of tolerance mechanisms, have been proposed in the literature, but a consolidating hypothesis that links these phenomena together has not appeared. Here, we outline a "thionitrate oxidation hypothesis," which attempts to link nitrate bioactivation and tolerance development in an overall mechanism. We also attempt to compare and contrast the proposed mechanism against existing theories of nitrate action and tolerance. Interactions between organic nitrates, which have been thought of as endothelium-independent agents, and the vascular endothelium and endothelial nitric oxide synthase (eNOS) are also discussed.
机译：有机硝酸盐（如硝酸甘油（NTG））已在医学中用作有效的血管扩张剂，但其生化作用机制，尤其是与耐受性发展有关的生化机制仍未完全定义。在文献中已经提出了许多用于NTG代谢的候选酶，以及多种耐受机制，但是尚未出现将这些现象联系在一起的综合假说。在这里，我们概述了一个“硫代硝酸盐氧化假说”，该假说试图将硝酸盐的生物活化和耐受性发展联系起来。我们还试图将所提出的机制与现有硝酸盐作用和耐受性理论进行比较和对比。还讨论了被认为是内皮依赖性药物的有机硝酸盐与血管内皮和内皮一氧化氮合酶（eNOS）之间的相互作用。

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