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首页> 外文期刊>Immunobiology: Zeitschrift fur Immunitatsforschung >Ability of antibodies specific to the HIV-1 envelope glycoprotein to block the fusion inhibitor T20 in a cell-cell fusion assay
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Ability of antibodies specific to the HIV-1 envelope glycoprotein to block the fusion inhibitor T20 in a cell-cell fusion assay

机译：HIV-1包膜糖蛋白特异性抗体在细胞-细胞融合测定中阻断融合抑制剂T20的能力

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摘要

The anti-HIV peptide T20 is able to inhibit the syncytia formation between CHO-WT and HeLa CD4 +cells. We found that several sera of HIV-infected patients have the capacity to block the inhibition of fusion by T20. Suggesting that these sera may contain antibody which can block T20 access and prevent membrane fusion, we studied the ability of a panel of antibodies directed to different regions of HIV-1 envelope glycoprotein to block the inhibition of fusion by T20. We found that the C1 and V3 loop regions of gp120 and the heptad repeat 1, the immunodominant C-C region and the Kennedy epitope of gp41 located in the intracytoplasmic tail were the target for antibodies capable to block the inhibition of syncytia formation by T20. We suggest that these antibodies have the capacity to counteract the anti-fusion effect of T20 by preventing its binding to the interaction sites. Further studies are needed to determine if some of them recognize new T20 interaction sites.
机译：抗HIV肽T20能够抑制CHO-WT与HeLa CD4 +细胞之间的合胞体形成。我们发现，几个感染了HIV的患者的血清具有阻断T20抑制融合的能力。提示这些血清可能含有可阻断T20进入并阻止膜融合的抗体，我们研究了针对HIV-1包膜糖蛋白不同区域的一组抗体阻断T20融合抑制的能力。我们发现gp120的C1和V3环区域以及七肽重复序列1，位于细胞质内尾的gp41的免疫优势C-C区和肯尼迪表位是能够阻断T20抑制合胞体形成的抗体的靶标。我们建议这些抗体具有通过阻止T20与相互作用位点结合来抵消其抗融合作用的能力。需要进一步研究以确定其中一些是否识别新的T20相互作用位点。

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