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首页> 外文期刊>Immunopharmacology and immunotoxicology >Mucous membrane pemphigoid affecting the oral cavity: Short review on etiopathogenesis, diagnosis and treatment
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Mucous membrane pemphigoid affecting the oral cavity: Short review on etiopathogenesis, diagnosis and treatment

机译：粘膜膜类天疱疮影响口腔：病因，诊断和治疗简述

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摘要

Oral mucous membrane pemphigoid (OMMP) is a rare inflammatory autoimmune mucocutaneous disorder. Oral mucosa is affected in 90% of cases. Its development is chronic, with a possible involvement of ocular, laryngeal and genital mucosa. Spontaneous remission is rare. Although the etiology of OMMP is still unclear, there is evidence that it is a complex autoimmune disease mediated by autoantibodies directed against different components of the basement membrane zone. Cellular immunity is also involved in the pathogenesis. Atrophic and erosive lesions are the sequelae of the rupture of the subepithelial blisters. The treatment is usually aimed at relieving pain and may include corticosteroids and immunosuppressive agents. However, the use of these drugs may be inefficacious. Oral hygiene and follow-up are mandatory for patients affected by OMMP. It is important to increase awareness of oral lesions in autoimmune blistering/erosive dermatologic conditions.
机译：口腔粘膜天疱疮（OMMP）是一种罕见的炎症性自身免疫性粘膜皮肤疾病。 90％的病例口腔粘膜受到影响。它的发展是慢性的，可能累及眼，喉和生殖器粘膜。自发缓解很少见。尽管OMMP的病因尚不清楚，但有证据表明它是由针对基底膜区不同成分的自身抗体介导的复杂的自身免疫疾病。细胞免疫也参与发病机理。萎缩性和侵蚀性病变是上皮下水泡破裂的后遗症。该治疗通常旨在缓解疼痛，并且可能包括皮质类固醇和免疫抑制剂。但是，使用这些药物可能无效。对于受OMMP影响的患者，必须进行口腔卫生和随访。重要的是提高自身免疫性水疱/糜烂性皮肤病学状况下口腔病变的认识。

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