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首页> 外文期刊>Immunity >CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha
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CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

机译：CD301b（+）单核吞噬细胞通过抵抗素样分子α的分泌维持正能量平衡

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摘要

Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b(+) CD11c(+) MHCII+ MNPs in multiple organs including adipose tissues. Depleting CD301b(+) MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) a, a multifunctional cytokine produced by MNPs. Reconstituting RELM alpha in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance.
机译：单核吞噬细胞（MNP）是高度异质的细胞群，在维持人体体内稳态中起重要作用。在这里，我们发现CD301b（也称为MGL2），一种通常用作交替激活的巨噬细胞标记的凝集素，由CD11b（+）CD11c（+）MHCII + MNPs的子集在包括脂肪组织在内的多个器官中选择性表达。体内耗尽CD301b（+）MNPs导致体重明显减轻，胰岛素敏感性增加，血清Resistin-like分子（RELM）a（由MNPs产生的多功能细胞因子）明显减少。在CD301b（+）MNP耗尽的动物中重建RELM alpha可恢复体重和正常血糖。因此，CD301b（+）MNPs在维持葡萄糖代谢和净能量平衡中起关键作用。

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