首页> 外文期刊>Immunological Investigations: A Journal of Molecular and Cellular Immunology >Natural killer cell activity, serum immunoglobulins, complement proteins, and zinc levels in patients with psoriasis vulgaris.
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Natural killer cell activity, serum immunoglobulins, complement proteins, and zinc levels in patients with psoriasis vulgaris.

机译:寻常型牛皮癣患者的自然杀伤细胞活性,血清免疫球蛋白,补体蛋白和锌水平。

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摘要

The role of the immune system in patients with psoriasis vulgaris (PV) was investigated. The genetic and immunological basis for psoriasis is still unknown. Because of the reports of immunological defects in this disease, we investigated serum levels of immunoglobulins IgG, IgM, IgA, complement proteins C3, C4, serum zinc (Zn) levels and natural killer (NK) cell activities. Skin lesions of the psoriatic patients involved in the study comprised less than 10 % of the total body and the disease was in a stationary period. Zn levels were measured by atomic absorption spectrophotometry. NK cell activity was measured by 51Cr (Na2 51CrO4). IgG, IgA, IgM, C3 and C4 assays were done by liquid-phase immunoprecipitation assay with nephelometric endpoint detection. IgG, IgA, C3 and C4 levels were significanty higher in patients with PV than in healty controls (p < 0.05). However, NK cell activity, serum Zn and IgM levels did not show significant differences between these two groups. There are changed immunological responses, which may play an important role in the pathogenesis of the disease. Many controversial results have been related to immunological parameters in psoriatic patients. Therefore, more detailed studies in this field need to be done to determine the relationship between psoriasis and the immune system.
机译:研究了免疫系统在寻常型牛皮癣(PV)患者中的作用。银屑病的遗传和免疫学基础仍然未知。由于该疾病存在免疫缺陷的报道,我们调查了免疫球蛋白IgG,IgM,IgA,补体蛋白C3,C4的血清水平,血清锌(Zn)水平和自然杀伤(NK)细胞活性。参与该研究的银屑病患者的皮肤病变仅占全身的不到10%,并且该疾病处于静止期。锌含量通过原子吸收分光光度法测量。 NK细胞活性通过51Cr(Na2 51CrO4)测定。 IgG,IgA,IgM,C3和C4检测通过液相免疫沉淀分析和浊度终点检测进行。 PV患者的IgG,IgA,C3和C4水平显着高于健康对照者(p <0.05)。然而,这两组之间的NK细胞活性,血清Zn和IgM水平没有显示出显着差异。免疫反应发生了变化,这可能在疾病的发病机理中起重要作用。许多有争议的结果与银屑病患者的免疫学参数有关。因此,需要在该领域进行更详细的研究,以确定牛皮癣和免疫系统之间的关系。

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