Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo.

Lefrancois L; Puddington L

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Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo.

机译：肠和肺粘膜T细胞：局部英雄奋战维持现状。

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Mucosal immunity in the lung and intestine is controlled by complex multifaceted systems. While mucosal T cells are essential for protection against invading pathogens owing to their proximity to the outside world, powerful systems must also be in place to harness ongoing inflammatory processes. In each site, distinct anatomical structures play key roles in mounting and executing both protective and deleterious mucosal T cell responses. Although analogies can be drawn regarding the immune systems of these two organs, there are substantial dissimilarities necessitated by unique physiologic constraints. Here, we discuss how T cell activation and effector function are generated in the mucosae.

机译：肺和肠的粘膜免疫受复杂的多方面系统控制。尽管粘膜T细胞由于其与外界的靠近而对于防止入侵的病原体是必不可少的，但还必须有强大的系统来利用正在进行的炎症过程。在每个部位，不同的解剖结构在安装和执行保护性和有害性粘膜T细胞反应中起关键作用。尽管可以对这两个器官的免疫系统进行类推，但由于独特的生理学限制，因此存在很大的差异。在这里，我们讨论如何在粘膜中产生T细胞激活和效应功能。

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《Annual Review of Immunology》 |2006年第0期|共24页
作者
Lefrancois L; Puddington L;
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正文语种 eng
中图分类基础医学;
关键词
T-Lymphocytes; Fighting; Intestinal; Pulmonary lt; 1gt; T淋巴细胞;

机译：T-Lymphocytes;Fighting;Intestinal;Pulmonary 1;T淋巴细胞;

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1. Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo. [J] . Lefrancois L, Puddington L Annual Review of Immunology . 2006,第0期

机译：肠和肺粘膜T细胞：局部英雄奋战维持现状。
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3. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. [J] . Pizarro TT, Michie MH, Bentz M, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第11期

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机译：舆论，媒体和环境政策：议程设置，框架和维持现状。
6. Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses [O] . Holm H. Uhlig, Fiona Powrie 2003

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机译：树突状细胞和肠道细菌菌群：局部黏膜免疫反应的作用。

Intestinal and pulmonary mucosal T cells: local heroes fight to maintain the status quo.

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