• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annual Review of Immunology >Compartmentalized Ras/MAPK signaling.
【24h】

Compartmentalized Ras/MAPK signaling.

机译：间隔的Ras / MAPK信号传导。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation, proliferation, and differentiation, has been generally considered to occur at the plasma membrane. It is now clear that the plasma membrane does not represent the only platform for Ras/MAPK signaling. Moreover, the plasma membrane itself is no longer considered a uniform structure but rather a patchwork of microdomains that can compartmentalize signaling. Signaling on internal membranes was first recognized on endosomes. Genetically encoded fluorescent probes for signaling events such as GTP/GDP exchange on Ras have revealed signaling on a variety of intracellular membranes, including the Golgi apparatus. In fibroblasts, Ras is activated on the plasma membrane and Golgi with distinct kinetics. The pathway by which Golgi-associated Ras becomes activated involves PLCgamma and RasGRP1 and may also require retrograde trafficking of Ras from the plasma membrane to the Golgi as a consequence of depalmitoylation. Thus, the Ras/MAPK pathway represents a clear example of compartmentalized signaling.
机译：通常认为，沿着Ras / MAPK通路的信号转导，包括对T细胞活化，增殖和分化至关重要的信号转导，发生在质膜上。现在很清楚，质膜并不代表Ras / MAPK信号传导的唯一平台。此外，质膜本身不再被认为是均匀的结构，而是可以将信号区分开的微区的拼凑而成。内膜上的信号首先在内体上被识别。用于信号转导事件（如Ras上GTP / GDP交换）的基因编码荧光探针已揭示出各种细胞内膜（包括高尔基体）上的信号转导。在成纤维细胞中，Ras以独特的动力学在质膜和高尔基体上被激活。与高尔基体相关的Ras被激活的途径涉及PLCgamma和RasGRP1，并且由于去棕榈酰化作用，还可能需要Ras从质膜向高尔基体的逆行运输。因此，Ras / MAPK途径代表了区隔信号转导的一个明显例子。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号