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首页> 外文期刊>Indian Journal of Pharmaceutical Education & Research >Conjugation of Polycarbophil: Preparation and Evaluation of Bilayered Buccoadhesive Tablet form Polycarbophil Conjugate
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Conjugation of Polycarbophil: Preparation and Evaluation of Bilayered Buccoadhesive Tablet form Polycarbophil Conjugate

机译：聚卡波非共轭物：聚卡波非共轭物形式的双层颊粘膜片剂的制备和评价

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摘要

The purpose of the present research envisaged was synthesize, characterize polycarbophil conjugate, to study the effect of conjugation on bioadhesion and drug release from the buccoadhesive tablet. The polycarbophil conjugate was synthesised by covalent attachment of thiol group of L-cysteine with the carboxylic acid group of polycarbophil. The synthesised conjugate was characterised by charring point determination, fourier transmission infra-red spectroscopic, differential scanning calorimetric analysis and measurement of gel strength. The bilayered buccoadhesive tablets provide the unidirectional diffusion. The drug core layer was prepared by various proportions of polycarbophil and polycarbophil conjugate with diltiazem hydrochloride. The backing layer was prepared by hydrophobic polymer Ethylcellulose. The buccoadhesive drug core was subjected to following evaluation tests such as weight uniformity, hardness, thickness, drug content, swelling index, moisture uptake, ex vivo bioadhesion strength, ex vivo bioadhesion time; in vitro drug release and in vitro drug permeation; ex vivo drug permeation was carried out in modified Franz diffusion cell. The study concluded that as the proportion of polycarbophil conjugate increased, increased drug release and drug permeation with enhanced ex vivo bioadhesive properties.
机译：所设想的本研究的目的是合成，表征聚卡波非共轭物，以研究共轭物对生物粘附性和从颊粘膜片剂中释放药物的影响。通过将L-半胱氨酸的巯基与聚卡波非的羧酸基团共价连接来合成聚卡波菲的共轭物。通过炭化点测定，傅立叶透射红外光谱，差示扫描量热分析和凝胶强度的测量来表征合成的缀合物。双层颊粘膜片剂可提供单向扩散。通过不同比例的聚卡波非和聚卡波非缀合物与盐酸地尔硫卓制备药物核心层。通过疏水性聚合物乙基纤维素制备背衬层。对该粘性粘着剂的药物核心进行了以下评估试验，例如重量均匀性，硬度，厚度，药物含量，溶胀指数，吸湿率，离体生物粘附强度，离体生物粘附时间。体外药物释放和体外药物渗透;在改良的Franz扩散池中进行离体药物渗透。研究得出结论，随着聚卡波非共轭物比例的增加，药物释放和药物渗透增加，离体生物粘附特性增强。

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