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首页> 外文期刊>Brain research >Orexin fibers form appositions with Fos expressing neuropeptide-Y cells in the grass rat intergeniculate leaflet.
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Orexin fibers form appositions with Fos expressing neuropeptide-Y cells in the grass rat intergeniculate leaflet.

机译：食欲素纤维与草大鼠间质小叶中的表达Fos的神经肽Y细胞并置。

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摘要

Neuropeptide-Y (NPY) cells in the intergeniculate leaflet (IGL) are known to modulate effects of arousal on the mammalian circadian system. However, the route through which this information reaches the IGL has not been established. Here, we provide evidence that the orexins (hypocretins) are uniquely positioned as a potential source of activity state feedback to the IGL in the grass rat, Arvicanthis niloticus. Specifically, many NPY cells in the grass rat IGL exhibit orexin-A (OXA) fiber appositions. Furthermore, NPY cells contacted by OXA fibers are significantly more likely to express Fos during nocturnal wheel running than are NPY cells without such contacts (P < 0.001).
机译：已知跨生叶（IGL）中的神经肽-Y（NPY）细胞可调节唤醒对哺乳动物昼夜节律系统的影响。但是，尚未建立此信息到达IGL的路径。在这里，我们提供了食欲素（hypocretins）被独特定位为草鼠Arvicanthis niloticus对IGL进行活动状态反馈的潜在来源。具体而言，草大鼠IGL中的许多NPY细胞都具有orexin-A（OXA）纤维并列。此外，与没有这种接触的NPY细胞相比，与夜间接触的NPY细胞相比，与夜间接触的NPY细胞更有可能表达Fos（P <0.001）。

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