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首页> 外文期刊>Brain research >Different types of barosensory synaptic inputs to rostral ventrolateral medulla neurons of the rat.
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Different types of barosensory synaptic inputs to rostral ventrolateral medulla neurons of the rat.

机译：大鼠鼻侧腹外侧延髓神经元的不同类型的压感突触输入。

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摘要

Neurons situated in the rostral ventrolateral medulla (RVLM) with descending axons to the spinal cord and that are modulated by different baroreceptor inputs are considered the main central generators of vasomotor activity. In the urethane-anesthetized, curarized rat, we recorded intracellular potentials from 14 neurons located in the RVLM and investigated their barosensory properties by analysis of the relation between neuronal membrane potential (MP), including spike potentials, and high-pressure barosensory activity, which was indicated by arterial blood pressure (BLPR). Time-domain (cross-correlations or triggered averaging) and frequency-domain (autospectra and coherences) analysis showed that 7 of 14 neurons had cardiac-cycle-correlated rhythms. EXCITATORY CARDIAC-CYCLE-RELATED MODULATION: One type of barosensitive neuron, with strong cardiac-related activity, was antidromically activated from the spinal cord and received inhibitory inputs from aortic nerve stimulation. These neurons had strong pulse-modulated activity consisting of EPSPs and spike potentials locked to the cardiac cycle and occurring at the end of diastole. INHIBITORY CARDIAC-CYCLE-RELATED MODULATION: Another type of barosensitive neuron showed hyperpolarizations locked to the cardiac cycle that started during late diastole and ended during the systolic period, but which had little relation to spike firing. The hyperpolarizations might be due to either IPSPs or disfacilitation. RESPIRATORY AND CARDIAC MODULATION: Some neurons also showed modulation of synaptic potentials and/or spike firing locked to the oscillation produced by ventilator pressure. It is suggested that the different types of cardiac- and respiratory-related rhythm reflect different functional roles of neurons in baroreceptor regulation of vasomotor activity.
机译：位于延髓腹侧延髓（RVLM）中的神经元具有下降的轴突到达脊髓，并由不同的压力感受器输入进行调节，被认为是血管舒缩活性的主要中央产生器。在经过尿烷麻醉的cur鼠中，我们记录了位于RVLM中的14个神经元的细胞内电位，并通过分析神经元膜电位（MP）（包括尖峰电位）与高压气压感觉活性之间的关系来研究其气压感觉特性，由动脉血压（BLPR）指示。时域（互相关或触发平均）和频域（自谱和相干性）分析表明，14个神经元中有7个具有与心动周期相关的节律。兴奋性心动循环相关的调节：一种具有强烈的心脏相关活性的压力敏感神经元，从脊髓被抗驱激活，并受到主动脉神经刺激的抑制性输入。这些神经元具有很强的脉冲调节活性，包括EPSP和锁定在心动周期上并发生在舒张末期的尖峰电位。抑制心脏循环相关的调制：另一种压力敏感神经元显示超极化被锁定在心脏周期上，该周期在舒张末期开始并在收缩期结束，但与尖峰放电关系不大。超极化可能是由于IPSP或疏忽造成的。呼吸和心脏调制：一些神经元还显示出突触电位的调制和/或峰值放电锁定在呼吸机压力产生的振荡上。建议不同类型的与心脏和呼吸有关的节律反映神经元在压力感受器调节血管舒缩活性中的不同功能作用。

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