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首页> 外文期刊>Brain research >Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists.
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Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists.

机译：通过使用AMPA，NMDA和DA D1受体拮抗剂进行预处理，可阻止对可卡因样杀真菌剂三唑酮的行为敏感性表达。

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Triadimefon (TDF) is a triazole fungicide that blocks the reuptake of dopamine (DA), much like cocaine. A recent study in our laboratory found that intermittent injections of TDF led to robust locomotor sensitization in response to challenge TDF after a 2-week withdrawal period. The current study sought to determine whether the expression of TDF behavioral sensitization could be prevented by the DA D1-like receptor antagonist SCH 23390 (SCH), the DA D2-like receptor antagonist remoxipride (Rem), the competitive NMDA antagonist CPP, or the AMPA antagonist NBQX. Adult male C57/BL6 mice were injected with vehicle or 75 mg/kg TDF twice a week for 7 weeks, with locomotor activity measured periodically across the 14 doses. After a 2-week withdrawal period, mice were pretreated with SCH (0.015 mg/kg), Rem (0.3 mg/kg), CPP (2.5 mg/kg) or NBQX (10.0 mg/kg) followed 30 min later by vehicle or 75 mg/kg TDF and tested for the expression of TDF sensitization. Intermittent administration of TDF led to the development and robust expression of behavioral sensitization in terms of vertical activity. Pretreatment with SCH, NBQX and CPP successfully blocked the expression of vertical sensitization to TDF, while Rem pretreatment did not. All four antagonists, however, attenuated the neurochemical changes normally associated with TDF sensitization as measured 8 h after the 2-week TDF challenge. This paper reveals that NMDA, AMPA and DA D1-like receptors are necessary for the behavioral expression of sensitization to the fungicide triadimefon.
机译：三唑酮（TDF）是一种三唑类杀菌剂，与可卡因很像，能阻止多巴胺（DA）的再摄取。我们实验室中的一项最新研究发现，在停药2周后，间歇性注射TDF会引起强烈的运动性敏化，以应对攻击性TDF。当前的研究试图确定是否可以通过DA D1样受体拮抗剂SCH 23390（SCH），DA D2样受体拮抗剂瑞莫必利（Rem），竞争性NMDA拮抗剂CPP或TPD行为敏化的表达来预防AMPA拮抗剂NBQX。每周两次向成年雄性C57 / BL6小鼠注射媒介物或75 mg / kg TDF，持续7周，并在14剂中定期测量运动能力。停药2周后，对小鼠进行SCH（0.015 mg / kg），Rem（0.3 mg / kg），CPP（2.5 mg / kg）或NBQX（10.0 mg / kg）预处理，然后在30分钟后用溶媒或75 mg / kg TDF并测试TDF致敏性表达。 TDF的间歇给药导致在垂直活动方面行为敏化的发展和健壮表达。 SCH，NBQX和CPP预处理成功地阻止了对TDF的垂直敏化表达，而Rem预处理则没有。然而，如在2周TDF攻击后8小时测得，所有四种拮抗剂均减弱了通常与TDF致敏有关的神经化学变化。本文揭示NMDA，AMPA和DA D1样受体对于杀菌剂三唑酮的致敏行为表达是必需的。

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