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首页> 外文期刊>Indian journal of physiology and pharmacology >Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alpha-fetoprotein.
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Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alpha-fetoprotein.

机译:血清铜,铜蓝蛋白,蛋白质硫醇和硫代巴比妥酸反应性物质状态与甲胎蛋白水平升高有关。

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摘要

Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.
机译:估计25例肝癌患者的血清铜,铜蓝蛋白,蛋白质硫醇和硫代巴比妥酸反应性物质(TEARS)。与对照组相比,肝癌患者中铜与铜蓝蛋白的比率适度增加(P <0.05),但铜(P <0.001)和铜蓝蛋白(P <0.001)水平显着增加。发现蛋白质硫醇水平非常显着(P <0.001)。由于TEARS水平不显着。微量元素和自由基与癌症的病因有关。因此,铜蓝蛋白和蛋白质硫醇以及铜的估计在癌症的早期诊断中可能具有很高的价值。

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