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NEUROBIOLOGY OF CANNABIS ADDICTION

机译:大麻成瘾的神经生物学

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摘要

Cannabis has emerged as a common substance of abuse and dependence and the peculiarities associated with this widely available and used substance has triggered substantial research in this field. The earlier held concept of rather benign nature of this compound as a substance of abuse and dependence has changed as a result of the ongoing clinical and research findings. Cannabis has been found to have multiple physical and mental effects in human beings. But still a lot remains to be answered regarding the basis for the development of dependence on cannabis. However, the discovery of various cannabis receptors and their endogenous and synthetic ligands have added fuel to the ever growing interest in this substance. Various hypotheses have been postulated in this regard based on the findings of both the animal and human studies which serve as potential explanations to the observations. These findings have helped in the better understanding of the issue and have provided substrate for the clinical application.
机译:大麻已经成为滥用和依赖的一种常见物质,与这种广泛获得和使用的物质有关的特殊性已触发了该领域的大量研究。由于正在进行的临床和研究发现,这种化合物作为滥用和依赖性物质的良性性质的较早提出的观念已经改变。大麻被发现对人类有多种身心影响。但是,关于依赖大麻发展的基础,仍然有很多问题需要解决。然而,各种大麻受体及其内源性和合成配体的发现为这种物质的日益增长的兴趣增加了燃料。在这方面,基于动物和人类研究的发现,已经提出了各种假设,这些假设可以作为对观察结果的潜在解释。这些发现有助于更好地理解该问题,并为临床应用提供了基础。

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