...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries.
【24h】

Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries.

机译：胸中或高腰椎不完全脊髓损伤大鼠的运动和电生理差异。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We have investigated the motor changes in rats subjected to a moderate photochemical injury on mid-thoracic (T8) or high lumbar (L2) spinal cord segments. Fourteen days after surgery, L2 injured animals presented gross locomotor deficits (scored 10+/-2.8 in the BBB scale), decreased amplitude of motor-evoked potentials (MEPs) recorded on tibialis anterior (TA) and plantar (PL) muscles (24% and 6% of the preoperative mean values, respectively), reduced M wave amplitudes (75%, 62%), and also facilitated monosynaptic reflexes evidenced by an increase of the H/M amplitude ratio (158% and 563%). On the other hand, T8 injured animals had only slight deficits in locomotion (18+/-0.6 in the BBB scale), a minimal reduction in MEP amplitudes (78% and 71% in TA and PL muscles), normal M wave amplitudes, and a milder increase of the H/M ratio in the TA muscle (191%) but less pronounced in the PL muscle (172%). The percentage of spared tissue at the site of injury was similar in both experimental groups (L2: 79% and T8: 82%). Taken together, these results indicate that lumbar spinal injuries have more severe consequences on hindlimb motor output than injuries exerted on thoracic segments. The causes of this anatomical difference may be attributed to damage inflicted on the central pattern generator of locomotion resulting in dysfunction of lumbar motoneurons and altered spinal reflexes modulation.
机译：我们已经研究了中胸（T8）或高腰（L2）脊髓节段遭受中度光化学损伤的大鼠的运动变化。手术后第14天，L2受伤的动物表现出总体运动缺陷（BBB评分为10 +/- 2.8），胫骨前肌（TA）和（肌（PL）上记录的运动诱发电位（MEP）幅度降低（24分别为术前平均值的5％和6％），M波振幅降低（75％，62％），并通过H / M振幅比的增加（158％和563％）证明了单突触反射。另一方面，受T8伤害的动物的运动能力仅有轻微缺陷（BBB评分为18 +/- 0.6），MEP幅度最小降低（TA和PL肌肉分别为78％和71％），M波幅度正常， TA肌肉中的H / M比值有轻微增加（191％），而PL肌肉中的H / M比则没有那么明显（172％）。在两个实验组中，受伤部位的备用组织百分比相似（L2：79％和T8：82％）。综上所述，这些结果表明，与施加在胸段上的损伤相比，腰椎损伤对后肢运动输出的影响更为严重。这种解剖学差异的原因可能归因于对运动的中央模式生成器造成的损害，导致腰椎运动神经元功能异常和脊柱反射调制改变。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号