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首页> 外文期刊>Brain research >Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model.
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Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model.

机译:YM872与t-PA共同在大鼠栓塞性中风模型中的神经保护作用。

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摘要

YM872, an AMPA receptor antagonist, was administered together with t-PA to investigate the effects of coadministration on neuroprotection in a rat embolic stroke model, when administered 2 h after embolism. T-PA or YM872 alone decreased infarct volume and improved the neurological deficit score. Coadministration of YM872 and t-PA resulted in a further decrease in infarct volume and improvement of the neurological score as compared with single administration of t-PA. These data demonstrate that coadministration of YM872 and t-PA produces more potent neuroprotective effects than when t-PA is administered alone.
机译:栓塞后2小时,将AMPA受体拮抗剂YM872与t-PA一起给药,以研究共同给药对大鼠栓塞性中风模型中神经保护作用的影响。单独使用T-PA或YM872可以减少梗塞体积并改善神经功能缺损评分。与单次使用t-PA相比,YM872和t-PA的并用导致梗塞体积进一步减少,神经系统评分得到改善。这些数据表明,与单独施用t-PA相比,YM872和t-PA的共同施用产生更有效的神经保护作用。

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