...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Simultaneous measurement of parasympathetic reflex vasodilator and arterial blood pressure responses in the cat.
【24h】

Simultaneous measurement of parasympathetic reflex vasodilator and arterial blood pressure responses in the cat.

机译：同时测量猫的副交感神经反射性血管舒张剂和动脉血压反应。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We measured the changes in lower lip blood flow and systemic arterial blood pressure evoked by lingual nerve or trigeminal spinal nucleus (Vsp) stimulation to gain an insight into the brainstem integration of sympathetic and parasympathetic responses to nociceptive stimulation. We used artificially ventilated, cervically vago-sympathectomized cats deeply anesthetized with alpha-chloralose and urethane. A lip blood flow increase occurred in an intensity- and frequency-dependent manner following electrical stimulation of Vsp or lingual nerve regardless of whether systemic arterial blood pressure increased or decreased. In contrast, there was no apparent optimal frequency for the changes in systemic arterial blood pressure elicited by electrical stimulation of Vsp or lingual nerve. No relationship was found between the amplitude of the lip blood flow increase and that of the systemic arterial blood pressure change. Microinjection of lidocaine or kainic acid into the Vsp evoked, respectively, reversible and irreversible inhibition of the lip blood flow increase and systemic arterial blood pressure change evoked by lingual nerve stimulation. When microinjected unilaterally directly into the ipsilateral Vsp, the GABA agonist muscimol abolished both lingual nerve-evoked effects (increase in lip blood flow and changes in systemic arterial blood pressure) without changing basal systemic arterial blood pressure, suggesting the presence in the Vsp of GABA receptors serving to modulate both the parasympathetically mediated lip blood flow increase and the sympathetically mediated systemic arterial blood pressure change. Lidocaine microinjection into the salivatory nucleus caused a significant attenuation of the lingual nerve-induced blood flow increase, but had no effect on the lingual nerve-induced systemic arterial blood pressure change. Thus, the neural pathway mediating the lingual nerve-induced lip blood flow increase seems to be simple, requiring a minimum of four neurons: trigeminal afferent-Vsp-parasympathetic pre-ganglionic neurons with cell body located in the inferior salivatory nucleus-otic postganglionic neuron. On the other hand, the pathway underlying the evoked systemic arterial blood pressure changes, presumably mediated via altered sympathetic activity, seems to be more complicated and could be affected by more numerous factors.
机译：我们测量了舌神经或三叉神经脊核（Vsp）刺激引起的下唇血流和全身动脉血压的变化，以了解伤害感受刺激的交感和副交感反应的脑干整合。我们使用人工通气，经宫颈迷路交感神经切除的猫，并用α-氯藻糖和氨基甲酸乙酯深度麻醉。 Vsp或舌神经的电刺激后，无论系统动脉血压升高还是降低，唇部血流的增加都以强度和频率相关的方式发生。相反，对于Vsp或舌神经的电刺激引起的系统性动脉血压变化，没有明显的最佳频率。在唇部血流的增加幅度与全身动脉血压的改变幅度之间没有关系。分别向诱发的Vsp中微量注射利多卡因或海藻酸，可逆性和不可逆性抑制舌血神经刺激引起的唇血流量增加和全身动脉血压变化。当单侧直接向同侧Vsp显微注射时，GABA激动剂muscimol消除了舌部神经诱发的作用（唇血流量的增加和全身动脉血压的变化），而没有改变基础全身动脉血压，表明GABA的Vsp中存在用于调节副交感神经介导的唇血流量增加和交感神经介导的全身动脉血压变化的受体。利多卡因显微注射到唾液核中导致舌神经引起的血流量增加明显减弱，但对舌神经引起的全身性动脉血压变化没有影响。因此，介导舌神经引起的唇血流量增加的神经途径似乎很简单，至少需要四个神经元：三叉神经传入-Vsp-副交感神经节前神经元，细胞体位于下唾液核-神经节后神经节中。 。另一方面，诱发的系统性动脉血压改变的潜在途径似乎更复杂，可能受更多因素影响，可能是由交感神经活动的改变介导的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号