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首页> 外文期刊>Brain research >Inherited tertiary hypothyroidism in Sprague-Dawley rats.
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Inherited tertiary hypothyroidism in Sprague-Dawley rats.

机译：Sprague-Dawley大鼠的遗传性第三甲状腺功能减退症。

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Thyroid hormones (THs) are important in the development and maturation of the central nervous system (CNS). The significant actions of THs during CNS development occur at the time when TH levels are lower than those in the mother and the hypothalamic-thyroid (HPT) axis is not fully functional. In the developing rat nervous system, primarily the cerebellum, the first three postnatal weeks represent a period of significant sensitivity to thyroid hormones. This study presents a spontaneous, inherited recessive hypothyroidism in Sprague-Dawley rats with devastating functional consequences to the development of the CNS. The clinical signs develop around 14 day's postnatal (dpn) and are characterized by ataxia, spasticity, weight loss and hypercholesterolemia. The afflicted rats died at 30 days due to severe neurological deficits. The deterioration affects the entire CNS and is characterized by progressive neuronal morphological and biochemical changes, demyelination and astrogliosis. The cerebellum, brain stem, neocortex, hippocampus and adrenal gland medulla appear to be most affected. Thyroid Stimulating Hormone (TSH), T3 and T4 levels were significantly lower in hypothyroid rats than control. Immunohistochemistry and RT-PCR demonstrated a reduction of Thyrotropin Releasing Hormone (TRH) in the hypothalamus of hypothyroid rats. The weight of both thyroid and pituitary glands were significantly less in hypothyroid rats than the corresponding normal littermate controls. Transmission electron microscopy demonstrates consistent postsynaptic dendritic, synaptic and spine alterative changes in the brain of hypothyroid rats. These data suggest that we discovered a tertiary form of inherited hypothyroidism involving the hypothalamus.
机译：甲状腺激素（THs）在中枢神经系统（CNS）的发育和成熟中很重要。 THs在中枢神经系统发育过程中的重要作用发生在TH水平低于母亲水平且下丘脑-甲状腺（HPT）轴功能不完全的时候。在发育中的大鼠神经系统（主要是小脑）中，产后前三个星期代表着对甲状腺激素高度敏感的时期。这项研究提出了Sprague-Dawley大鼠自发性遗传性隐性甲状腺功能减退症，对CNS的发展具有毁灭性的功能性后果。临床体征大约在产后14天（dpn）出现，并以共济失调，痉挛，体重减轻和高胆固醇血症为特征。患病的大鼠由于严重的神经功能缺损在30天时死亡。这种恶化影响整个中枢神经系统，其特征是神经元的形态和生化进行性改变，脱髓鞘和星形胶质细胞变性。小脑，脑干，新皮质，海马和肾上腺髓质受到的影响最大。甲状腺功能减退大鼠的甲状腺刺激激素（TSH），T3和T4水平显着低于对照组。免疫组织化学和RT-PCR证实甲状腺功能减退大鼠下丘脑的促甲状腺激素释放激素（TRH）降低。甲状腺功能减退大鼠甲状腺和垂体的重量均显着低于相应的正常同窝仔对照。透射电子显微镜显示甲状腺功能减退大鼠的大脑中突触后突触，突触和脊柱的变化一致。这些数据表明我们发现了涉及下丘脑的遗传性甲状腺功能减退症的第三种形式。

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