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首页> 外文期刊>Brain research >A learned odor decreases the number of Fos-immunopositive granule cells in the olfactory bulb of young rats.
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A learned odor decreases the number of Fos-immunopositive granule cells in the olfactory bulb of young rats.

机译：闻到的气味减少了幼鼠嗅球中Fos免疫阳性颗粒细胞的数量。

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摘要

Olfactory stimulation evokes a column of activity within the olfactory bulb extending from the glomerular layer to the granule cell layer that can be visualized with 2-deoxyglucose autoradiography, optical imaging, Fos protein immunohistochemistry and c-fos mRNA in situ hybridization. The Fos response to odors is typified by the activity of relatively few juxtaglomerular cells, which often occur in foci, and a large number of granule cells extending through much of the bulb. In this study, we characterized the granule cell response to an odor for which young rats had acquired a preference. Fos-like immunoreactive granule cells were quantified by image analysis, and densely stained cells were counted in a region previously shown to be responsive to peppermint odor. We found that odor-trained pups have about half the number of Fos-immunopositive superficial granule cells which respond to a learned odor than do control pups. We then determined whether there was a correlation between the juxtaglomerular cell response and the response of the superficial granule cells deep to those glomerular layer cells. We found a positive correlation between the number of juxtaglomerular cells and the number of granule cells demonstrating Fos immunoreactivity in both control and trained pups, a relationship that changed with early olfactory training.
机译：嗅觉刺激引起了嗅球内从肾小球层到颗粒细胞层的一列活动，可以通过2-脱氧葡萄糖放射自显影，光学成像，Fos蛋白免疫组织化学和c-fos mRNA原位杂交来观察。 Fos对气味的反应的典型特征是相对较少的近肾小球细胞（通常发生在病灶中）的活动，以及大量散布在整个球茎中的颗粒细胞。在这项研究中，我们表征了颗粒细胞对气味的反应，年轻的老鼠对此有偏好。通过图像分析定量Fos样免疫反应性颗粒细胞，并在先前显示出对薄荷气味有反应的区域中计数密集染色的细胞。我们发现，经过气味训练的幼犬对福斯免疫阳性浅表颗粒细胞的数量是对照幼犬的一半，后者对学习到的气味做出反应。然后，我们确定了近肾小球细胞反应与这些肾小球层细胞深处的浅表颗粒细胞的反应之间是否存在相关性。我们发现在对照和训练后的幼崽中，肾小球细胞数量与颗粒细胞数量之间表现出正相关性，这与Fos免疫反应性呈正相关，这种关系随着早期嗅觉训练而改变。

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