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首页> 外文期刊>Brain research >Alcohol consumption alters dopamine transporter sites in Wistar-Kyoto rat brain.
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Alcohol consumption alters dopamine transporter sites in Wistar-Kyoto rat brain.

机译：饮酒会改变Wistar-Kyoto大鼠大脑中的多巴胺转运蛋白位点。

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Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the present study examined the effects of chronic alcohol consumption on DAT sites in WKY versus Wistar (WIS) rats. Brains from both strains were sectioned for autoradiographic analysis of [3H]-GBR12935 binding to DAT sites after 24 days of alcohol exposure. The results indicated that WKY rats consumed a greater amount of alcohol (P < 0.001) than WIS rats did throughout the experiment. Autoradiographic analyses of discrete brain regions indicated that alcohol consumption increased DAT sites in a greater number of brain areas in WKY compared to WIS rats. In WKY rats, the binding of [3H]-GBR12935 to DAT sites was increased in the basolateral, central and lateral nuclei of the amygdala, lateral nucleus of the hypothalamus, olfactory tubercle, caudate-putamen, nucleus accumbens and substantia nigra (P < 0.05) and decreased in the ventromedial nucleus of the hypothalamus and the CA1 region of the hippocampus. In WIS rats, alcohol consumption increased DAT sites in the CA1 region of the hippocampus, basolateral nucleus of the amygdala, ventral tegmental area and substantia nigra, and decreased DAT sites in the lateral and ventromedial hypothalamus and dentate gyrus. These results indicate a strain dependent alteration in DAT sites which may be related to altered dopamine neurotransmission in select brain regions following alcohol consumption.
机译：即使动物和人体研究显示戒酒后多巴胺转运蛋白（DAT）的位点发生了变化，但DAT在影响酗酒或抑郁行为中的作用尚未得到广泛研究。鉴于Wistar-Kyoto（WKY）大鼠是抑郁行为的推定动物模型，因此本研究研究了长期饮酒对WKY与Wistar（WIS）大鼠DAT位点的影响。酒精暴露24天后，将这两种菌株的大脑切成薄片进行[3H] -GBR12935与DAT部位结合的放射自显影分析。结果表明，在整个实验过程中，WKY大鼠比WIS大鼠消耗更多的酒精（P <0.001）。离散脑区的放射自显影分析表明，与WIS大鼠相比，饮酒增加了WKY大脑中更多区域的DAT位点。在WKY大鼠中，[3H] -GBR12935与DAT位点的结合在杏仁核的基底外侧，中央和外侧核，下丘脑外侧核，嗅结节，尾状壳，核伏伏核和黑质（P < 0.05）并在下丘脑腹侧核和海马CA1区减少。在WIS大鼠中，饮酒会增加海马CA1区，杏仁核的基底外侧核，腹侧被盖区和黑质的DAT位点，而外侧和腹侧下丘脑和齿状回的DAT位点减少。这些结果表明，DAT部位的应变依赖性改变可能与饮酒后某些大脑区域的多巴胺神经传递改变有关。

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