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首页> 外文期刊>Brain research >The dopamine D1 receptor agonist, but not the D2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens.
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The dopamine D1 receptor agonist, but not the D2 receptor agonist, induces gene expression of Homer 1a in rat striatum and nucleus accumbens.

机译：多巴胺D1受体激动剂而不是D2受体激动剂诱导大鼠纹状体和伏隔核中Homer 1a的基因表达。

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Stimulation of dopamine receptors may induce striatal Homer 1a, an immediate-early gene (IEG) that is involved in the molecular mechanism for the signaling pathway of the group I metabotropic glutamate receptors. This study examined the effects of the agonists for dopamine D(1)-like and D(2)-like receptors on gene expression of Homer 1a, in comparison with the IEG c-fos expression, in the discrete brain regions of rats. The D(1)-like agonist SKF38393 (20 mg/kg, s.c.) significantly increased the mRNA levels of Homer 1a in the striatum and nucleus accumbens, but not in the medial prefrontal cortex or hippocampus, 2 h after injection, whereas the D(2)-like agonist quinpirole (1 mg/kg, s.c.) had no significant effect on Homer 1a mRNA levels in any brain region examined. Co-administration of SKF38393 and quinpirole significantly increased Homer 1a mRNA levels in the striatum, nucleus accumbens and hippocampus, while this effect was not significantly greater than that of SKF38393 alone. Any treatment did notaffect the mRNA levels of other splicing variants, Homer 1b or 1c. In contrast, combination of both dopamine agonists produced a greater increase than SKF38393 did in the mRNA levels of c-fos in the nucleus accumbens, striatum and substantia nigra. These results suggest that stimulation of D(1)-like receptors, but not D(2)-like receptors, may induce gene expression of Homer 1a in the striatum and nucleus accumbens. However, in contrast to c-fos expression, it is unlikely that co-activation of both D(1)-like and D(2)-like receptors exerts a synergic action on Homer 1a expression in these regions.
机译：多巴胺受体的刺激可能诱导纹状体荷马1a，即一种早期基因（IEG），该基因与I组代谢型谷氨酸受体信号通路的分子机制有关。这项研究检查了多巴胺D（1）-样和D（2）-样受体的激动剂对大鼠离散脑区荷马1a基因表达的影响，与IEG c-fos表达相比。 D（1）样激动剂SKF38393（20 mg / kg，sc）显着增加了注射后2 h纹状体和伏隔核中荷马1a的mRNA水平，但未在内侧前额叶皮层或海马中增加了Homer 1a的mRNA水平。 （2）样激动剂喹吡罗（1 mg / kg，sc）对所检查的任何大脑区域的荷马1a mRNA水平均无明显影响。共同施用SKF38393和喹吡罗可显着增加纹状体，伏隔核和海马中Homer 1a mRNA的水平，但这种作用并不比单独使用SKF38393大得多。任何处理均不影响其他剪接变体Homer 1b或1c的mRNA水平。相比之下，两种多巴胺激动剂的组合在伏伏核，纹状体和黑质中的c-fos mRNA水平上的增加均大于SKF38393。这些结果表明刺激D（1）样受体，但不是D（2）样受体，可能会诱导纹状体和伏隔核中荷马1a的基因表达。但是，与c-fos表达相反，D（1）样和D（2）样受体的共同激活不太可能对这些区域的Homer 1a表达产生协同作用。

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