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首页> 外文期刊>Brain research >Autocorrelogram sorting: A novel method for evaluating negative-feedback regulation of spike firing.
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Autocorrelogram sorting: A novel method for evaluating negative-feedback regulation of spike firing.

机译：自相关图分类：一种评估尖峰发射负反馈调节的新颖方法。

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Spontaneously firing units were recorded extracellularly from the hippocampus of anesthetized rats, and autocorrelograms were conventionally constructed. These conventional autocorrelograms were sorted into frequency-specific autocorrelograms according to the instantaneous firing frequency of the spike at Deltat=0, which was calculated based on the interval between the spike at Deltat=0 and the preceding spike. In this fashion, we found that autocorrelogram values were negatively correlated with instantaneous firing frequency during the 4-12 ms post-spike time period. The negative correlation during the 4-6 ms post-spike period could not have been due to the refractory period or GABAergic inhibition, and thus represented a third type of feedback regulation of spike firing completed within single neurons. Application of acetylcholine significantly enhanced this feedback regulation. Our 'autocorrelogram sorting' method thus proved to be successful in detecting cholinergically enhanced feedback regulationof spike firing intrinsic to single neurons.
机译：从麻醉大鼠海马的细胞外记录自发放电单位，并按常规建立自相关图。根据Deltat = 0处尖峰的瞬时触发频率，将这些常规自相关图分类为特定频率的自相关图，该频率是根据Deltat = 0处的尖峰与之前的尖峰之间的间隔计算得出的。以这种方式，我们发现自相关图值与峰值后4-12毫秒的瞬时触发频率呈负相关。峰值后4-6 ms期间的负相关可能不是由于不应期或GABA能抑制引起的，因此代表了在单个神经元内完成的峰值发射的第三种反馈调节。乙酰胆碱的应用显着增强了这种反馈调节。因此，我们的“自相关图分类”方法成功地检测了胆碱能增强的单个神经元内在放电的反馈调节。

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