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Non-neoformans Cryptococcal Infections: a Systematic Review.

机译：非新甲虫隐球菌感染：系统评价。

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Non-neoformans cryptococci have been generally regarded as saprophytes and rarely reported as human pathogens. However, the incidence of infection due to these organisms has increased over the past 40 years, with Cryptococcus laurentii and Cryptococcus albidus, together, responsible for 80% of reported cases. Conditions associated with impaired cell-mediated immunity are important risks for non-neoformans cryptococcal infections and prior azole prophylaxis has been associated with antifungal resistance. The presence of invasive devices was a significant risk factor for Cryptococcus laurentii infection (adjusted OR = 8.7; 95% CI = 1.48-82.9; p = 0.003), while predictors for mortality included age >/=45 years (aOR = 8.4; 95% CI = 1.18-78.82; p = 0.004) and meningeal presentation (aOR = 7.0; 95% CI = 1.85-60.5; p= 0.04). Because clinical manifestations of non-neoformans cryptococcal infections are most often indistinguishable from Cryptococcus neoformans, a high index of suspicion remains important to facilitate early diagnosis and prompt treatment for such infections.
机译：非新甲虫隐球菌通常被认为是腐生菌，很少被报道为人类病原体。然而，在过去的40年中，由于这些微生物引起的感染发生率有所增加，劳伦隐球菌和白色隐球菌一起占报告病例的80％。与细胞介导的免疫功能降低相关的疾病是非新甲虫隐球菌感染的重要风险，以前的预防吡咯与抗真菌药耐药性有关。侵入性器械的存在是劳氏隐球菌感染的重要危险因素（校正OR = 8.7; 95％CI = 1.48-82.9; p = 0.003），而死亡率的预测因素包括年龄> / = 45岁（aOR = 8.4; 95） ％CI ＝ 1.18-78.82; p ＝ 0.004）和脑膜呈现（aOR ＝ 7.0; 95％CI ＝ 1.85-60.5; p ＝ 0.04）。由于非新甲型隐球菌感染的临床表现通常与新隐球菌无法区分，因此高度怀疑仍对促进此类感染的早期诊断和及时治疗很重要。

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