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首页> 外文期刊>Infection >Chronic Vasculitis and Polyneuropathy due to Infection with Bartonella henselae.
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Chronic Vasculitis and Polyneuropathy due to Infection with Bartonella henselae.

机译：感染半夏巴尔通体引起的慢性血管炎和多发性神经病。

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摘要

Bartonella henselae, the causative agent of cat scratch disease and bacillary angiomatosis, is associated with an expanding spectrum of diseases. Here, we report on a 40-year-old patient suffering from chronic recurrent painful ulcers of the toes, distal axonal sensomotor polyneuropathy and Raynaud's phenomenon. Biopsy of the sural nerve demonstrated an axonal neuropathy with a neurogenic muscular atrophy. Treatment with high dose corticosteroids had no beneficial effect. A biopsy taken from a recurring ulcer 7 years after the beginning of the disease revealed superficial ulcerated hyperkeratosis with subepithelial proliferation of small vessels compatible with a diagnosis of verruca peruana, however, without detection of microorganism. Serologic analysis revealed an elevated IFT titer of 1:1,024 against B. henselae. Treatment with erythromycin induced healing of the ulcer, remission of the vasculitis and the polyneuropathy, and a decline of the IFT titer. This case illustrates that B. henselae infection should be considered in patients with vasculitis and polyneuropathic syndromes.
机译：亨氏巴尔通体是猫抓痕病和细菌性血管瘤病的病原体，与疾病范围扩大有关。在这里，我们报道了一名40岁的患者，该患者患有慢性复发性脚趾溃疡，远端轴突感觉运动性多发性神经病和Raynaud现象。腓肠神经的活检显示为轴突性神经病，并伴有神经源性肌肉萎缩。用大剂量皮质类固醇治疗无益处。疾病开始7年后从复发性溃疡中进行的活检显示，溃疡性角化过度，小血管上皮下增生，可诊断为疣疣，但未发现微生物。血清学分析显示，针对汉森芽孢杆菌的IFT滴度提高到1：1024。红霉素治疗可引起溃疡愈合，血管炎和多发性神经病缓解，以及IFT滴度下降。该病例说明，患有血管炎和多发性神经病综合征的患者应考虑感染汉逊杆菌。

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