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首页> 外文期刊>Infection >Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment--a retrospective analysis in 38 children with cystic fibrosis.
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Leukocytopenia, thrombocytopenia and fever related to piperacillin/tazobactam treatment--a retrospective analysis in 38 children with cystic fibrosis.

机译：与哌拉西林/他唑巴坦治疗有关的白细胞减少，血小板减少和发烧-对38例囊性纤维化儿童的回顾性分析。

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摘要

Bone marrow suppression is an important adverse reaction to most betalactam antibiotics. Recently it was suggested that piperacillin/tazobactam (PT) also may cause bone marrow toxicity. We retrospectively analyzed 100 i.v. antibiotic treatment courses (mean duration 12.5 days) in 38 patients (median age 14 years) with cystic fibrosis (CF) who were treated in our hospital. Of the patients receiving PT (84%), 6 patients (18.75% of PT-treated patients, 10.3% of PT treatment courses) developed fever, malaise and headache during treatment without signs of acute infection. In one patient definite thrombocytopenia and neutropenia, in two others a milder decrease in leukocyte and thrombocyte counts was observed after the onset of fever. The events were time- and dose-dependent occurring between day 11 and 15 of treatment. Treatment courses lasted longer (14.2 vs 11.3 days; p < 0.05) and patients had received a higher cumulative dose of PT (4919 +/- 1975 mg/kg b.w. vs 3161 +/- 1635 mg/kg; p < 0.02, Student's t-test) in the affected group than in the unaffected group. After discontinuation of PT, fever subsided within 24 h and blood cell counts normalized. We hypothesize that these fever episodes and changes of blood parameters are related to PT therapy.
机译：骨髓抑制是对大多数β-内酰胺抗生素的重要不良反应。最近，有人提出哌拉西林/他唑巴坦（PT）也可能引起骨髓毒性。我们回顾性分析了100 i.v.在我们医院接受治疗的38例囊性纤维化（CF）患者（平均年龄14岁）进行了抗生素治疗（平均疗程12.5天）。在接受PT的患者中（84％），有6例患者（接受PT治疗的患者占18.75％，占PT治疗疗程的10.3％）在治疗期间出现发烧，全身乏力和头痛，而没有急性感染的迹象。在一名患者中，确定的血小板减少症和中性粒细胞减少症，在另外两名患者中，发烧后观察到白细胞和血小板计数的轻度降低。在治疗的第11天至第15天之间，事件是时间和剂量依赖性的。治疗过程持续时间更长（14.2 vs 11.3天; p <0.05），并且患者接受了更高的PT累积剂量（4919 +/- 1975 mg / kg bw vs 3161 +/- 1635 mg / kg; p <0.02，学生t -test），而不是未受影响的组。停用PT后，发烧在24小时内消退，血细胞计数恢复正常。我们假设这些发烧发作和血液参数的变化与PT治疗有关。

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