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首页> 外文期刊>Infection >Experimental contamination of a closed endotracheal suction system: 24 h vs 72 h.
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Experimental contamination of a closed endotracheal suction system: 24 h vs 72 h.

机译：密闭气管内抽吸系统的实验污染：24小时与72小时。

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OBJECTIVE: To ascertain the desirability of replacing closed suction systems after 72 h rather than after 24 h (manufacturer's recommendations) because it is possible that a reduction in the frequency of manipulations might reduce the risk of exogenous nosocomial pneumonia. We investigated the presence of time-dependent differences (after 24 h and 72 h) in pathogen survival/growth in artificially contaminated closed suction catheters (OptiFlo). DESIGN: The trial simulated bacterial contamination of the airways using a suspension of 2 x 10(3) CFU/ml of Staphylococcus aureus or Pseudomonas aeruginosa. Contamination was performed on a total of 80 catheters. Forty were contaminated a total of eight times every 45-60 min. Another 40 catheters underwent the same procedure 24 times over three consecutive days. Microbiological analysis of the catheters took place after 24 h and 72 h, respectively. RESULTS: The mean S. aureus load was 9.4 CFU/catheter after eight suction procedures and 6.2 CFU/catheter after 24suction procedures (3 days). Mean growth of P. aeruginosa was 5.3 CFU/catheter, and 8.2 CFU/catheter after 3 days. There was no statistically significant difference between day 1 and 3 for S. aureus (p = 0.474), but there was for P. aeruginosa (p = 0.004). CONCLUSION: Our findings show that, from an experimental point of view, it remains controversial whether routine change of closed suction catheters can be extended from 24 h to 72 h. However, clinical evidence suggests that prolonged use of a closed suctioning system is safe.
机译：目的：为了确定在72小时后而不是24小时后（制造商的建议）更换封闭式吸气系统的必要性，因为减少操作频率可能会降低外源性医院内肺炎的风险。我们调查了在人工污染的封闭式抽吸导管（OptiFlo）中病原体存活/生长的时间依赖性差异（分别在24小时和72小时之后）的存在。设计：该试验使用2 x 10（3）CFU / ml金黄色葡萄球菌或铜绿假单胞菌的悬浮液模拟了气道的细菌污染。总共对80个导管进行了污染。每45-60分钟共污染四十次，共四十次。在连续三天中，另外40个导管进行了相同的操作24次。导管的微生物学分析分别在24小时和72小时后进行。结果：八次抽吸手术后，平均金黄色葡萄球菌负荷为9.4 CFU /导管，而24抽吸手术后（3天），平均金黄色葡萄球菌负荷为6.2 CFU /导管。铜绿假单胞菌的平均生长在3天后为5.3 CFU /导管，和8.2 CFU /导管。金黄色葡萄球菌在第1天和第3天之间没有统计学上的显着差异（p = 0.474），但铜绿假单胞菌也没有（p = 0.004）。结论：我们的发现表明，从实验的角度来看，封闭式抽吸导管的常规更换能否从24小时延长至72小时仍存在争议。但是，临床证据表明，长时间使用封闭的抽吸系统是安全的。

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