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首页> 外文期刊>Brain research. Brain research protocols >The Suok ('ropewalking') murine test of anxiety.
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The Suok ('ropewalking') murine test of anxiety.

机译：Suok（“走行”）小鼠焦虑测试。

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In the present study, we suggest that long elevated horizontal rod (Suok test, ST) and its light-dark modification (LDST) may be used for behavioral characterization in mice, including simultaneous assessment of their anxiety, activity, and neurological phenotypes. To establish the ST and the LDST as murine models of anxiety, we used several different mouse strains which differ markedly in their anxiety and activity (C57BL/6, 129S1/SvImJ, NMRI, and BALB/c). Here we show that our tests are able to ethologically discriminate between high and low anxiety mouse strains, as assessed by horizontal and directed exploration, stops, and defecation boli. The spatial distribution of the LDST behaviors is also sensitive to these strain-specific anxiety phenotypes, showing clear avoidance of the brightly lit part of the test in stressed (rat exposed) vs. control NMRI mice. In addition, we validated the ST in 129S1/SvImJ and BALB/c mice by assessing the behavioral consequences of acute stress such as rat exposure. Finally, we showed that our test is able to detect high anxiety and poorer motor coordination in 129S1/SvImJ (vs. C57BL/6) mice. The results of our study show that the ST emerges as an experimental tool to analyze anxiety, motor-vestibular anomalies, as well as anxiety-induced motor impairments in mice. Overall, we suggest that the ST can be a useful protocol in neurobehavioral stress research including modeling stress-evoked states, pharmacological screening of potential anti-stress drugs, or behavioral phenotyping of genetically modified animals.
机译：在本研究中，我们建议将较长的水平横杆（Suok测试，ST）及其明暗修饰（LDST）用于小鼠的行为表征，包括同时评估其焦虑，活动和神经表型。为了建立ST和LDST作为小鼠的焦虑模型，我们使用了几种不同的小鼠品系，它们的焦虑和活性明显不同（C57BL / 6、129S1 / SvImJ，NMRI和BALB / c）。在这里，我们证明了我们的测试能够从水平和定向探索，停止和排便玻利进行评估，从种族学角度上区分高和低焦虑小鼠品系。 LDST行为的空间分布也对这些特定于应变的焦虑表型敏感，显示出在压力大（暴露于大鼠）与对照NMRI小鼠中，避免了测试的明亮部分。此外，我们通过评估急性应激（如大鼠暴露）的行为后果，验证了129S1 / SvImJ和BALB / c小鼠的ST。最后，我们证明了我们的测试能够检测129S1 / SvImJ（相对于C57BL / 6）小鼠的高焦虑症和较弱的运动协调能力。我们的研究结果表明，ST可以作为一种分析小鼠焦虑，运动性前庭异常以及焦虑性运动障碍的实验工具。总的来说，我们建议ST可以成为神经行为应激研究的有用方案，包括模拟应激诱发状态，潜在抗应激药物的药理筛选或转基因动物的行为表型。

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