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首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Phylodynamics of HIV-1 unique recombinant forms in China-Myanmar border: Implication for HIV-1 transmission to Myanmar from Dehong, China
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Phylodynamics of HIV-1 unique recombinant forms in China-Myanmar border: Implication for HIV-1 transmission to Myanmar from Dehong, China

机译：中国-缅甸边境HIV-1独特重组形式的植物动力学：从中国德宏向缅甸传播HIV-1的意义

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摘要

China-Myanmar border plays a crucial role in HIV-1 transmission in Asia. Here, we performed Bayesian phylodynamics analyses on pi 7 gene using BEAST to investigate HIV-1 transmission in this region. Maximum clade credibility trees of subtype C and CRF01_AE show that majority of unique recombinant forms (URFs) and pure subtype strains from Dehong and Myanmar cluster together, forming large clades with ancestral geographical states of Dehong. Bayes factor tests support the statistically significant geographic diffusion link between Dehong and Myanmar. The estimated time to the most recent common ancestor of Myanmar URFs_BC (1999.2) was later than that of Dehong URFs_BC (1998.0), but earlier than that of Myanmar URFs_01BC (2004.3). Since 1998, HIV-1 recombination between subtypes B, C and CRF01_AE has been continuously occurring in China-Myanmar border region. These results suggest that HIV-1 subtypes B, C and CRFOl_AE were most likely transmitted from Dehong to Myanmar, and predict that URFs_01BC should be also prevalent in Dehong, Yunnan.
机译：中缅边境在亚洲的HIV-1传播中起着至关重要的作用。在这里，我们使用BEAST对pi 7基因进行了贝叶斯系统动力学分析，以调查该区域的HIV-1传播。 C和CRF01_AE亚型的最大进化枝信誉树显示，来自德宏和缅甸的大多数独特重组形式（URF）和纯亚型菌株聚集在一起，形成了具有德宏祖先地理状态的大型进化枝。贝叶斯因子检验支持了德宏和缅甸之间具有统计意义的地理扩散联系。到缅甸URFs_BC（1999.2）的最近共同祖先的估计时间晚于Dehong URFs_BC（1998.0），但比缅甸URFs_01BC（2004.3）早。自1998年以来，中缅边境地区B，C和CRF01_AE亚型之间的HIV-1重组一直持续发生。这些结果表明，HIV-1亚型B，C和CRFO1_AE最有可能从德宏传播到缅甸，并预测URFs_01BC在云南德宏也应普遍存在。

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