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首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Phylogenetics of HIV-1 subtype G env: Greater complexity and older origins than previously reported
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Phylogenetics of HIV-1 subtype G env: Greater complexity and older origins than previously reported

机译：HIV-1亚型G env的系统发育学：比以前报道的更为复杂，来源更老

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HIV-1 subtype G has played an early and central role in the emergent complexity of the HIV-1 group M (HIV-1M) epidemic in central/west Africa. Here, we analysed new subtype G env sequences sampled from 8 individuals in Yaounde, Cameroon during 2007-2010, together with all publically available subtype G-attributed full-length env sequences with known sampling dates and locations. We inferred that the most recent common ancestor (MRCA) of the analysed subtype G env sequences most likely occurred in similar to 1953 (95% Highest Posterior Density interval [HPD] 1939-1963): about 15 years earlier than previous estimates. We found that the subtype G env phylogeny has a complex structure including seven distinct lineages, each likely dating back to the late 1960s or early 1970s. Sequences from Angola, Gabon and the Democratic Republic of Congo failed to group consistently in these lineages, possibly because they are related to more ancient sequences that are poorly sampled. The circulating recombinant form (CRF), CRF06_cpx env sequences but not CRF25_cpx env sequences are phylogenetically nested within the subtype G clade. This confirms that the CRF06_cpx env plausibly was derived through recombination from a subtype G parent, and suggests that the CRF25_cpx env was likely derived from an HIV-1M lineage related to the MRCA of subtype G that has remained undiscovered and may be extinct. Overall, this fills important gaps in our knowledge of the early events in the spread of HIV-1M. (C) 2015 Elsevier B.V. All rights reserved.
机译：HIV-1 G亚型在中非/西非的HIV-1 M群（HIV-1M）流行的复杂性中起了早期和核心作用。在这里，我们分析了在2007-2010年期间从喀麦隆雅温得的8个个体中采样的新亚型G env序列，以及所有已知日期和位置的公共可获取的亚型G归属全长env序列。我们推断，分析的G亚型亚型env序列的最新共同祖先（MRCA）最有可能发生在类似于1953年（95％最高后密度间隔[HPD] 1939-1963年）的情况：比以前的估计值早了15年。我们发现，亚型G env系统发育具有复杂的结构，包括七个不同的世系，每个世系都可以追溯到1960年代末或1970年代初。来自安哥拉，加蓬和刚果民主共和国的序列未能在这些谱系中一致地分组，可能是因为它们与采样较差的更古老的序列有关。循环重组形式（CRF），CRF06_cpx env序列而非CRF25_cpx env序列在系统发育上嵌套在亚型G进化枝内。这证实了CRF06_cpx env可能是通过重组从G亚型亲本中获得的，并表明CRF25_cpx env可能源自与G亚型MRCA有关的HIV-1M谱系，该谱系尚未被发现并且可能已经灭绝。总体而言，这填补了我们对HIV-1M传播早期事件认识的重要空白。 （C）2015 Elsevier B.V.保留所有权利。

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