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首页> 外文期刊>Inflammatory bowel diseases >Acute pancreatitis in patients with Crohn's disease: clinical features and outcomes.
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Acute pancreatitis in patients with Crohn's disease: clinical features and outcomes.

机译：克罗恩病患者的急性胰腺炎：临床特征和结局。

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BACKGROUND: Acute pancreatitis has occasionally been associated with Crohn's disease (CD), but whether a causal association exists remains unclear. We sought to determine the frequency of etiologies in a consecutive series of patients with CD with acute pancreatitis. METHODS: A centralized diagnostic index was used to identify all patients with CD with acute pancreatitis that were evaluated at Mayo Clinic Rochester between 1976 and 2001. Both diagnoses were made or confirmed at our institution. Records were abstracted for demographics, presenting symptoms, diagnostic tests, risk factors of pancreatitis, treatment, and follow-up. RESULTS: Forty-eight patients with CD with pancreatitis were identified. The median age at diagnosis of acute pancreatitis was 47 years (range, 31-91 yr). Forty-six (96%) met biochemical criteria for acute pancreatitis. The most sensitive radiographic tests were abdominal computed tomography (70%) and abdominal ultrasound (46%). The etiology of pancreatitis was considered to begallstones (21%), significant alcohol intake (15%), use of purine analogs (13%), duodenal Crohn's involvement (12%), postendoscopic retrograde cholangiopancreatography complications (10%), postoperative complications (12%), use of other medications (4%) and idiopathic (8%). The median length of hospitalization was 7 days (range, 0-40 d). Ten patients (21%) had recurrence of acute pancreatitis. Three patients (6%) were subsequently diagnosed with pancreatic cancer. CONCLUSIONS: A definite etiology could be identified in most patients with CD with acute pancreatitis. Gallstones and alcohol accounted for more than one third of cases, whereas CD, either because of duodenal involvement or medications used for its treatment, accounted for more than one quarter of the cases. A small proportion of patients remained idiopathic.
机译：背景：急性胰腺炎有时与克罗恩病（CD）有关，但尚不清楚是否存在因果关系。我们试图确定一系列连续性急性胰腺炎CD患者的病因频率。方法：1976年至2001年间，在梅奥诊所罗切斯特（Mayo Clinic Rochester）进行评估的集中诊断指标用于鉴定所有患有急性胰腺炎的CD患者。两种诊断均在我们机构进行或确认。提取记录以用于人口统计，表现出症状，诊断测试，胰腺炎的危险因素，治疗和随访。结果：鉴定出48例患有CD的胰腺炎患者。诊断为急性胰腺炎的中位年龄为47岁（范围31-91岁）。四十六（96％）符合急性胰腺炎的生化标准。最敏感的影像学检查是腹部计算机断层扫描（70％）和腹部超声（46％）。胰腺炎的病因被认为是石结石（21％），大量饮酒（15％），使用嘌呤类似物（13％），十二指肠克罗恩受累（12％），内镜后逆行胰胆管造影术并发症（10％），术后并发症（ 12％），使用其他药物（4％）和特发性（8％）。中位住院时间为7天（范围0-40 d）。十例（21％）复发了急性胰腺炎。随后三名患者（6％）被诊断为胰腺癌。结论：大多数CD合并急性胰腺炎的患者可以明确病因。胆结石和酒精占病例的三分之一以上，而CD（由于十二指肠受累或用于治疗的药物）占病例的四分之一以上。一小部分患者仍然是特发性的。

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