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首页> 外文期刊>Brain research >Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila.
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Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila.

机译：抗惊厥药丙戊酸盐可降低果蝇突变体的癫痫发作敏感性。

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Despite the frequency of seizure disorders in the human population, the genetic basis for these defects remains largely unclear. Currently, only a fraction of the epilepsies can be linked conclusively to a genetic determinant. In addition, a significant number of epileptics do not respond to the current anticonvulsant therapies. We have turned to Drosophila as a model to address these problems and have identified genetic mutants that are more sensitive to seizures, bang-sensitive (BS) mutants, such as slamdance (sda), bangsenseless (bss) and easily shocked (eas), as well as mutants that are resistant to seizures, such as paralytic, maleless(napts), shaking-B(2) and Shaker. Here, we have developed a new method for evaluating compounds with anticonvulsant activity. The methodology uses Drosophila BS mutants to assay the ability of compounds to suppress the seizure susceptible phenotype normally seen in the BS mutants. To test the effectiveness of this method, two BS mutant strains were administered the anticonvulsant valproate and in both cases the drug was able to suppress seizures. The Drosophila system provides a potentially powerful way of developing and testing new drugs with anticonvulsant properties.
机译：尽管人群中癫痫发作的频率很高，但这些缺陷的遗传基础仍不清楚。目前，只有一小部分的癫痫病可以确定性地与遗传决定簇相连。另外，大量的癫痫药对当前的抗惊厥疗法没有反应。我们已将果蝇作为解决这些问题的模型，并确定了对癫痫发作更敏感的遗传突变体，砰击敏感（BS）突变体，例如猛击（sda），无刺无感（bss）和易受惊吓（eas），以及对癫痫病具有抵抗力的突变体，例如麻痹型，无性（小睡），摇动B（2）和摇床。在这里，我们开发了一种新的方法来评估具有抗惊厥活性的化合物。该方法使用果蝇BS突变体来分析化合物抑制通常在BS突变体中可见的癫痫发作易感表型的能力。为了测试该方法的有效性，向抗癫痫药丙戊酸给药了两种BS突变菌株，在两种情况下，该药物均能抑制癫痫发作。果蝇系统提供了开发和测试具有抗惊厥特性的新药的潜在强大方法。

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