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首页> 外文期刊>British Journal of Haematology >Overcoming HLA-DPB1 donor specific antibody-mediated haematopoietic graft failure.
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Overcoming HLA-DPB1 donor specific antibody-mediated haematopoietic graft failure.

机译:克服HLA-DPB1供体特异性抗体介导的造血移植失败。

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摘要

Primary and secondary graft failure (GF) remain a major complication of allogeneic haematopoietic stem cell transplantation (HSCT). Multiple factors have been implicated in GF, including the use of mismatched donors, T-cell depleted grafts, reduced-intensity conditioning and ABO blood group mismatch (Mattsson et al, 2008). However, most cases cannot be attributed to a single factor. Donor specific antibodies (DSA) have only recently been recognized as a factor implicated in graft failure(Ciurea et al, 2010; Spellman et al, in press), particularly in mismatched transplants(Ciurea et al, 2009).A 63-year-old man was referred to our centre for unrelated HSCT for relapsed lymphoplasmacytic lymphoma (LPL) and therapy-induced bone marrow failure.
机译:原发性和继发性移植失败(GF)仍然是同种异体造血干细胞移植(HSCT)的主要并发症。 GF涉及多种因素,包括使用不匹配的供体,T细胞耗竭的移植物,降低强度的调节和ABO血型不匹配(Mattsson等,2008)。但是,大多数情况不能归因于单个因素。供体特异性抗体(DSA)直到最近才被认为是与移植失败相关的因素(Ciurea等,2010; Spellman等,印刷中),特别是在错配的移植物中(Ciurea等,2009)。63年一位老人因复发性淋巴浆细胞性淋巴瘤(LPL)和治疗引起的骨髓衰竭被送往我们无关的HSCT中心。

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