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首页> 外文期刊>Brain research bulletin >Behavioral and dorsal raphe neuronal activity following acute and chronic methylphenidate in freely behaving rats
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Behavioral and dorsal raphe neuronal activity following acute and chronic methylphenidate in freely behaving rats

机译：自由行为大鼠急性和慢性哌醋甲酯后行为和背沟神经元活动

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Concomitant behavioral and dorsal raphe (DR) neuronal activity were recorded following acute and chronic dose response of methylphenidate (MPD) in freely moving rats previously implanted with permanent semi-microelectrodes using telemetric (wireless) technology. On experimental day (ED) 1, the neuronal and locomotor activity were recorded after saline (baseline) and MPD (0.6, 2.5 or 10.0. mg/kg) injection (i.p.). Animals were injected daily with a single dose of MPD for five consecutive days (ED 2-6) to elicit behavioral sensitization or tolerance. After three washout days, the neuronal and locomotor activity recording was resumed on ED 10 followed by saline and MPD rechallenge injection. The main findings were: (1) the same dose of chronic MPD administration elicited behavioral sensitization in some animals and behavioral tolerance in others. (2) 46%, 56% and 73% of DR units responded to acute 0.6, 2.5 and 10.0. mg/kg MPD respectively. (3) 89%, 70% and 86% of DR units changed their baseline activity on ED 10 compared to that on ED 1 in the 0.6, 2.5 and 10.0. mg/kg MPD groups respectively. (4) A significant difference in ED 10 baseline activity was observed in the DR neuronal population recording from animals expressing behavioral sensitization compared to that of animals expressing behavioral tolerance. (5) 89%, 78% and 88% of DR units responded to chronic 0.6, 2.5 and 10.0. mg/kg MPD respectively. (6) The DR neuronal population recording following acute MPD on ED 1 and rechallenge MPD on ED 10 from animals expressing behavioral sensitization was significantly different from the neuronal population recorded from animals exhibited behavioral tolerance. The correlation between the DR neuronal activity and animal's behavior following chronic MPD exposure suggested that the DR neuronal activity may play an important role in the expression of behavioral sensitization and tolerance induced by chronic MPD administration.
机译：在先前使用遥测（无线）技术植入永久性半微电极的自由移动大鼠中，记录哌醋甲酯（MPD）的急性和慢性剂量反应后，记录了伴随的行为和背脊（DR）神经元活动。在实验第1天（ED），注射生理盐水（基线）和MPD（0.6、2.5或10.0。mg / kg）（腹膜内）后记录神经元和运动能力。每天连续五天（ED 2-6）给动物注射单剂量的MPD，以引起行为敏化或耐受性。冲洗三天后，在ED 10上恢复神经元和运动活性的记录，然后注射生理盐水和MPD。主要发现是：（1）相同剂量的长期MPD给药引起某些动物的行为敏化，而另一些动物引起行为耐受。 （2）46％，56％和73％的DR单位对急性0.6、2.5和10.0有反应。分别为mg / kg MPD。 （3）在0.6、2.5和10.0中，与ED 1相比，在ED 10上有89％，70％和86％的DR单位改变了其基线活性。 mg / kg MPD组。 （4）与表现行为耐受的动物相比，在表现行为敏化的动物的DR神经元记录中观察到ED 10基线活性存在显着差异。 （5）89％，78％和88％的DR单位对慢性0.6、2.5和10.0有反应。分别为mg / kg MPD。 （6）表现行为敏化的动物在ED 1上急性MPD和ED 10的再挑战MPD之后记录的DR神经元群体与表现出行为耐受性的动物记录的DR神经元群体显着不同。慢性MPD暴露后DR神经元活动与动物行为之间的相关性表明，DR神经元活动可能在慢性MPD给药诱导的行为敏化和耐受性表达中起重要作用。

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