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首页> 外文期刊>Brain research. Brain research protocols >Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice.
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Amyloid beta protein deposition and neuron loss in osteopetrotic (op/op) mice.

机译：骨质疏松（op / op）小鼠的淀粉样β蛋白沉积和神经元丢失。

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Formation of senile plaques (SPs) by amyloid beta (Abeta) protein is a neuropathological change which characterizes Alzheimer's disease (AD), and Abeta deposition and neuron loss are essential for the pathological cascade of the disease. Although the mechanism of Abeta deposition remains unclear, it has been suggested that clearance of Abeta protein may be impaired in the AD brain. Previous studies demonstrated that microglia were able to remove Abeta by releasing a metalloprotease or by phagocytosis, suggesting that microglia may play an important role in preventing Abeta deposition in the central nervous system (CNS). On the other hand, it was reported that the number of microglia was reduced in osteopetrotic (op/op) toothless mice resulting from the lack of functional macrophage colony-stimulating factor (M-CSF). The present study was thus designed to examine the Abeta deposition and the number of hippocampal neurons in the brain of op/op mice. A number of fibrillar plaques were detected in the cerebral cortex, hippocampus, amygdala and hypothalamus in op/op mice, however, no quantitative evidence of Abeta deposition was observed in normal mice. Moreover, the total number of pyramidal cells in the hippocampal CA1, and CA3 regions was significantly reduced in op/op mice when compared to the controls. These results demonstrate that Abeta deposition influence neuron loss and it may be suspected that expression of SPs may be in part regulated by microglia under physiological conditions.
机译：淀粉样β（Abeta）蛋白形成的老年斑（SPs）是神经病理学变化，是阿尔茨海默病（AD）的特征，而Abeta沉积和神经元丢失对于该疾病的病理级联至关重要。尽管尚不清楚Abeta沉积的机制，但已表明AD脑中Abeta蛋白的清除可能受到损害。先前的研究表明，小胶质细胞能够通过释放金属蛋白酶或通过吞噬作用去除Abeta，这表明小胶质细胞可能在阻止Abeta在中枢神经系统（CNS）沉积中起重要作用。另一方面，据报道，由于缺乏功能性巨噬细胞集落刺激因子（M-CSF），骨质疏松（op / op）无牙小鼠的小胶质细胞数量减少。因此，本研究旨在检查op / op小鼠大脑中的Abeta沉积和海马神经元数量。在op / op小鼠的大脑皮层，海马，杏仁核和下丘脑中检测到许多原纤维斑，但是，在正常小鼠中未观察到Abeta沉积的定量证据。此外，与对照组相比，op / op小鼠的海马CA1和CA3区锥体细胞总数明显减少。这些结果表明，Abeta沉积会影响神经元的损失，并且可能怀疑在生理条件下小胶质细胞可能部分调节了SP的表达。

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