Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium

CampaD.; MartinoA.; SainzJ.; BudaG.; JamroziakK.; WeinholdN.; ReisR.M.V.; García-SanzR.; JuradoM.; RíosR.; Szemraj-RoguckaZ.; MarquesH.; LesueurF.; BugertP.; MorenoV.; SzemrajJ.; OrciuoloE.; GemignaniF.; RossiA.M.; DumontetC.; PetriniM.; GoldschmidtH.; LandiS.; CanzianF.

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Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium

机译：综合研究8q24地区的遗传变异和IMMEnSE联盟的多发性骨髓瘤风险

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Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies.

机译：全基因组关联研究（GWAS）显示，即使缺少基因，8q24区域也包含多个独立的癌症易感基因座。鉴于目前尚无多发性骨髓瘤（MM）的GWAS数据，我们检验了这一区域的遗传变异可能在MM风险中起作用的假设。我们对1188例MM病例和2465例对照的8q24的20个单核苷酸多态性进行了基因分型，发现rs2456449与MM风险之间存在统计学上的显着相关性（P = 0·0022）。这些数据提供了进一步的证据，证明8q24区域的遗传变异性与癌症风险特别是血液恶性肿瘤有关。

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《British Journal of Haematology》 |2012年第3期|共8页
作者
CampaD.; MartinoA.; SainzJ.; BudaG.; JamroziakK.; WeinholdN.; ReisR.M.V.; García-SanzR.; JuradoM.; RíosR.; Szemraj-RoguckaZ.; MarquesH.; LesueurF.; BugertP.; MorenoV.; SzemrajJ.; OrciuoloE.; GemignaniF.; RossiA.M.; DumontetC.; PetriniM.; GoldschmidtH.; LandiS.; CanzianF.;
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正文语种 eng
中图分类血液及淋巴系疾病;
关键词
Cancer; Cancer genetics; Epidemiology; Genetics; Haematological malignancies; Myeloma;

机译：癌症;癌症遗传学;流行病学;遗传学;血液系统恶性肿瘤;骨髓瘤;

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专利

1. Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium [J] . CampaD., MartinoA., SainzJ., British Journal of Haematology . 2012,第3期

机译：综合研究8q24地区的遗传变异和IMMEnSE联盟的多发性骨髓瘤风险
2. Genetic variation at the 8q24 locus confers risk to multiple myeloma. [J] . Tewari P, Ryan AW, Hayden PJ, British Journal of Haematology . 2012,第1期

机译：8q24位点的遗传变异会导致多发性骨髓瘤。
3. Genetics and molecular epidemiology of multiple myeloma: The rationale for the IMMEnSE consortium (Review) [J] . Alessandro Martino, Juan Sainz, Gabriele Buda, International journal of oncology . 2011,第3期

机译：多发性骨髓瘤的遗传学和分子流行病学：IMMEnSE联盟的基本原理（综述）
4. Cytogenetic Abnormalities in Multiple Myeloma [C] . M. Paluszewska, J. Dwilewicz-Trojaczek, H. Stanczak, European Haematology Association . 2002

机译：多发性骨髓瘤中的细胞遗传学异常
5. Genetic risk factors in multiple myeloma [D] . Rand, Kristin Alyse 2012

机译：多发性骨髓瘤的遗传危险因素
6. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium [O] . Federico Canzian, David G. Cox, V. Wendy Setiawan, -1

机译：NCI乳腺癌和前列腺癌队列研究中与类固醇激素和胰岛素样生长因子-I代谢相关的61个基因的常见遗传变异的综合分析和乳腺癌风险
7. Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium [O] . Campa Daniele, García-Sanz Ramón, Canzian Federico 2012

机译：综合研究8q24地区的遗传变异和IMMEnSE联盟的多发性骨髓瘤风险

Comprehensive investigation of genetic variation in the 8q24 region and multiple myeloma risk in the IMMEnSE consortium

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