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首页> 外文期刊>British Journal of Haematology >The impact of HFE mutations on haemoglobin and iron status in individuals experiencing repeated iron loss through blood donation
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The impact of HFE mutations on haemoglobin and iron status in individuals experiencing repeated iron loss through blood donation

机译：HFE突变对因献血反复失血的个体的血红蛋白和铁状态的影响

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摘要

Frequent blood donors become iron deficient. HFE mutations are present in over 30% of donors. A 24-month study of 888 first time/reactivated donors and 1537 frequent donors measured haemoglobin and iron status to assess how HFE mutations impact the development of iron deficiency erythropoiesis. Donors with two HFE mutations had increased baseline haemoglobin and iron stores as did those with one mutation, albeit to a lesser extent. Over multiple donations haemoglobin and iron status of donors with HFE mutations paralleled those lacking mutations. The prevalence of HFE mutations was not increased in higher intensity donors. Thus, in general, HFE mutations do not temper donation-induced changes in haemoglobin and iron status. However, in Black donors there was an increase of H63D carriers at baseline, from 3·7% in first time/reactivated donors to 15·8% in frequent donors, suggesting that the relative effects of HFE mutations on iron absorption may vary between racial/ethnic groups. In secondary analyses, venous haemoglobin decreased more slowly in donors with ferritin ≥12μg/l; and haemoglobin recovery time was shorter in donors with reticulocyte haemoglobin (CHr) ≥32·6pg, indicating that these biochemical measures are better indicators of a donor's response to phlebotomy than their HFE mutation status.
机译：频繁的献血者铁缺乏。 HFE突变存在于超过30％的供体中。一项针对888名首次/重新激活的供体和1537名频繁供体的24个月研究测量了血红蛋白和铁的状况，以评估HFE突变如何影响缺铁性红细胞生成的发展。具有两个HFE突变的供体和具有一个突变的供体的基线血红蛋白和铁存储增加，尽管程度较小。在多次捐赠中，具有HFE突变的捐赠者的血红蛋白和铁状态与那些缺乏突变的捐赠者平行。在较高强度的供体中，HFE突变的患病率没有增加。因此，一般而言，HFE突变不会抑制捐赠诱导的血红蛋白和铁状态的变化。但是，黑人供体的基线H63D携带者有所增加，从首次/再次激活的供体的3·7％增至频繁的供体的15·8％，这表明种族之间HFE突变对铁吸收的相对影响可能有所不同。 /种族团体。在第二次分析中，铁蛋白≥12μg/ l的供体的静脉血红蛋白下降更为缓慢。网状细胞血红蛋白（CHr）≥32·6pg的供血者的血红蛋白恢复时间更短，表明这些生化措施比HFE突变状态更好地指示了供血者对放血的反应。

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