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首页> 外文期刊>British Journal of Haematology >Regression of a renal cell carcinoma following allogeneic peripheral blood stem cell transplant for acute myeloid leukaemia: Evidence of a graft-versus-tumour effect without significant graft-versus-host disease
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Regression of a renal cell carcinoma following allogeneic peripheral blood stem cell transplant for acute myeloid leukaemia: Evidence of a graft-versus-tumour effect without significant graft-versus-host disease

机译：同种异体外周血干细胞移植治疗急性髓性白血病后肾细胞癌的消退：无明显移植物抗宿主病的移植物抗肿瘤作用的证据

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摘要

A 66-year-old man presented with haematuria and flank pain. Computed tomography (CT) imaging showed a 9.5 x 8.2 cm mass in the right kidney (asterisk, left), consistent with a renal cell carcinoma. He was also significantly pancytopenic; bone marrow examination revealed an extensive infiltrate of myeloblasts (CD34+, CD117+, myeloperoxidase+) and trilineage dysplasia. Cytogenetic analysis demonstrated three related cell lines all with monosomy 7 and additional abnormalities of trisomy 13, t(2;16)(qll; q11) and idic(22), establishing the diagnosis of acute myeloid leukaemia (AML) with myelodysplasia-related changes. In view of these poor prognostic features, treatment of the AML was prioritized and he received standard daunorubicin plus cytarabine induction chemotherapy. However, he achieved complete remission (CR) only after salvage with FLAG-Ida (fludarabine, cytarabine, idarubicin and lenograstim). This was consolidated with a matched, unrelated-donor allogeneic stem cell transplant (SCT) with conditioning according to the Seattle protocol. Interval CT imaging prior to the SCT demonstrated no significant reduction in size of the renal mass.
机译：一名66岁的男子出现血尿和胁腹疼痛。计算机断层扫描（CT）成像显示右肾（星号，左）为9.5 x 8.2 cm肿块，与肾细胞癌一致。他还具有明显的全血细胞减少症。骨髓检查显示成纤维细胞（CD34 +，CD117 +，髓过氧化物酶+）和三系谱异常增生广泛浸润。细胞遗传学分析显示，三个相关的细胞系均具有7号单体性以及13号三体性的其他异常，t（2; 16）（qll; q11）和idic（22），从而建立了与骨髓增生异常相关的急性髓性白血病（AML）的诊断。鉴于这些不良的预后特征，AML的治疗被优先考虑，他接受了标准的柔红霉素联合阿糖胞苷诱导化疗。但是，只有在用FLAG-Ida（氟达拉滨，阿糖胞苷，伊达比星和来诺格司亭）打捞后，他才达到完全缓解（CR）。根据西雅图协议，将其与条件匹配的匹配的，无关的供体同种异体干细胞移植（SCT）合并在一起。 SCT之前的间隔CT成像显示肾脏肿块没有明显减少。

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