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首页> 外文期刊>British Journal of Haematology >Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes
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Prognostic value of trisomy 8 as a single anomaly and the influence of additional cytogenetic aberrations in primary myelodysplastic syndromes

机译：三体性8作为单一异常的预后价值以及其他细胞遗传异常在原发性骨髓增生异常综合症中的影响

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摘要

Trisomy 8 is the most common chromosomal gain in myelodysplastic syndromes (MDS), however, little is known about the features of MDS with isolated trisomy 8 and the influence of additional cytogenetic aberrations. We determined the characteristics and prognostic factors of 72 patients with trisomy 8 as a single anomaly and analysed also the impact of other aberrations added to trisomy 8 in another 62 patients. According to our study, MDS with isolated trisomy 8 was more frequent in men, with more than one cytopenia in most patients (62%) and having about 4% bone marrow blasts. The multivariate analysis demonstrated that platelet count and percentage bone marrow blasts had the strongest impact on overall survival (OS). The median OS for isolated trisomy 8, trisomy 8 plus one aberration (tr8 + 1), plus two (tr8 + 2) and plus three or more aberrations (tr8 + ≥3) was 34·3, 40, 23·4 and 5·8 months, respectively (P < 0·001). Trisomy 8 confers a poorer prognosis than a normal karyotype in MDS patients with ≥5% bone marrow blasts. This study supports the view that MDS with isolated trisomy 8 should be included in the intermediate cytogenetic risk group.
机译：三体性8是骨髓增生异常综合症（MDS）中最常见的染色体增益，但是，关于分离的三体性8的MDS的特征以及其他细胞遗传畸变的影响知之甚少。我们确定了72例三体性三例患者的特征和预后因素为单个异常，并分析了另外62例患者中添加到8体三体性中的其他像差的影响。根据我们的研究，具有独立三体性8的MDS在男性中更为常见，大多数患者中有1个以上的血细胞减少症（62％），骨髓母细胞约4％。多元分析表明，血小板计数和骨髓胚细胞百分率对总生存期（OS）的影响最大。孤立的三体性8，三体性8加一个像差（tr8 + 1），加上两个（tr8 + 2）和加上三个或更多像差（tr8 +≥3）的中位OS为34·3、40、23·4和5 ·分别为8个月（P <0·001）。与≥5％骨髓原始细胞的MDS患者相比，三体8的预后较正常核型差。这项研究支持这样的观点，即具有隔离的三体性8的MDS应该包括在中等细胞遗传学风险组中。

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