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Antibody responses against influenza A(H1N1)pdm09 virus after sequential vaccination with pandemic and seasonal influenza vaccines in Finnish healthcare professionals

机译：芬兰卫生保健专业人员连续接种大流行和季节性流感疫苗后对A（H1N1）pdm09流感病毒的抗体反应

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Background Influenza A(H1N1)pdm09 virus has been circulating in human population for three epidemic seasons. During this time, monovalent pandemic and trivalent seasonal influenza vaccination against this virus have been offered to Finnish healthcare professionals. It is, however, unclear how well vaccine-induced antibodies recognize different strains of influenza A(H1N1)pdm09 circulating in the population and whether the booster vaccination with seasonal influenza vaccine would broaden the antibody cross-reactivity. Objectives Influenza vaccine-induced humoral immunity against several isolates of influenza A(H1N1)pdm09 virus was analyzed in healthcare professionals. Age-dependent responses were also analyzed. Methods Influenza viruses were selected to represent viruses that circulated in Finland during two consecutive influenza epidemic seasons 2009-2010 and 2010-2011. Serum samples from vaccinated volunteers, age 20-64years, were collected before and after vaccination with AS03-adjuvanted pandemic and non-adjuvanted trivalent seasonal influenza vaccine that was given 1year later. Results Single dose of pandemic vaccine induced a good albeit variable antibody response. On day 21 after vaccination, depending on the virus strain, 14-75% of vaccinated had reached antibody titers (≥1:40) considered seroprotective. The booster vaccination 1year later with a seasonal vaccine elevated the seroprotection rate to 57-98%. After primary immunization, younger individuals (20-48years) had significantly higher antibody titers against all tested viruses than older persons (49-64years) but this difference disappeared after the seasonal booster vaccination. Conclusions Even a few amino acid changes in influenza A HA may compromise the vaccine-induced antibody recognition. Older adults (49years and older) may benefit more from repeated influenza vaccinations.
机译：背景甲型（H1N1）pdm09流感病毒已在​​三个流行季节在人群中传播。在这段时间内，已经向芬兰卫生保健专业人员提供了针对这种病毒的单价大流行和三价季节性流感疫苗。但是，尚不清楚疫苗诱导的抗体如何很好地识别人群中循环的不同A型流感病毒（H1N1）pdm09株，以及季节性流感疫苗的加强疫苗接种是否会扩大抗体的交叉反应性。目的在专业医护人员中分析了流感疫苗诱导的针对几种分离的A（H1N1）pdm09流感病毒的体液免疫。还分析了年龄依赖性反应。方法选择流感病毒代表在2009-2010年和2010-2011年连续两个流感流行季节在芬兰传播的病毒。在接种AS03辅助大流行和非辅助三价季节性流感疫苗接种前后，分别收集了20-64岁年龄在20-64岁的志愿者的血清样本。结果单剂大流行疫苗可产生良好的抗体反应，但反应良好。疫苗接种后第21天，根据病毒株的不同，接种疫苗的14-75％已达到认为具有血清保护性的抗体滴度（≥1：40）。 1年后使用季节性疫苗加强免疫，将血清保护率提高到57-98％。初次免疫后，相对于老年人（49-64岁），年轻人（20-48岁）对所有测试病毒的抗体效价明显更高，但这种差异在季节性加强免疫后消失。结论甲型流感病毒中即使有几个氨基酸变化也可能损害疫苗诱导的抗体识别。年龄较大的成年人（49岁及以上）可能会从反复的流感疫苗接种中受益更多。

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