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Modulation of the endocrine and immune systems by well-controlled hyper-thermia equipment

机译：良好控制的高温设备对内分泌和免疫系统的调节

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Since high levels of hyperthermia induce immunosuppression to a certain extent (i.e., granulocyto-sis and lymphocytopenia) in patients, we applied mild hyperthermia in volunteers using equipment enabling well-controlled hyperthermia. Restricted control of rectal temperature at 39.4 (± 0.2)°C for 30 min was conducted and various parameters of the body were examined. The most prominent change observed during exposure to hyperthermia was elevated levels of pH and PO2 in the blood, even in the venous blood. A transient elevation of ACTH, cortisol and growth hormone in the blood was also seen during this time. In parallel with this phenomenon, the number of total lymphocytes and those of its subsets (especially CD57+ or CD56+ NK cells and NKT cells) increased. More interestingly, the proportion of HLA-DR (MHC class II antigens) increased in NK and NKT cells, and their intensity on the surface of CD20+ B cells increased. These results suggest that mild hyperthermia is important for modulation of the functions of the circulatory, endocrine and immune systems.
机译：由于高水平的体温过高会在一定程度上诱发患者的免疫抑制（即粒细胞增多症和淋巴细胞减少症），因此我们使用能够控制良好的体温过高的设备在志愿者中应用了温和的体温过高。将直肠温度限制在39.4（±0.2）°C进行30分钟控制，并检查身体的各种参数。暴露于热疗期间观察到的最显着变化是血液（甚至静脉血）中pH和PO2含量升高。在这段时间内，还发现血液中ACTH，皮质醇和生长激素的短暂升高。与此现象同时出现的是，总淋巴细胞及其亚群（尤其是CD57 +或CD56 + NK细胞和NKT细胞）的数量增加了。更有趣的是，NK和NKT细胞中HLA-DR（II类MHC抗原）的比例增加，并且它们在CD20 + B细胞表面的强度增加。这些结果表明，温和的高温对于调节循环系统，内分泌系统和免疫系统的功能很重要。

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