...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>British Journal of Haematology >Enhanced and aberrant T cell trafficking following total body irradiation: A gateway to graft-versus-host disease?
【24h】

Enhanced and aberrant T cell trafficking following total body irradiation: A gateway to graft-versus-host disease?

机译：全身照射后增强和异常的T细胞运输：移植物抗宿主病的途径？

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pre-transplant conditioning regimens play a major role in triggering graft-versus-host disease (GVHD). This study investigated the effect of irradiation on donor T cell trafficking to lymphoid and non-lymphoid tissues by comparing the migration of carboxy-fluorescein diacetate succinimidyl ester-labelled, na?ve donor T lymphocytes in vivo in irradiated and non-irradiated syngeneic mice recipients. Recruitment of adoptively transferred na?ve T cells to secondary lymphoid organs was increased in irradiated mice and na?ve T cells also aberrantly localized to non-lymphoid tissues. Irradiation also induced aberrant effector memory T cell migration into lymph nodes and their localization to homing-privileged non-lymphoid sites, such as the gut. The presence of a minor histocompatibility mismatch further enhanced the aberrant accumulation of T cells in both lymphoid and non-lymphoid tissue, whilst their migratory pattern was not modified as compared to fully matched irradiated recipients. These effects correlated with decreased permeability of, and the secretion of chemotactic factors by the endothelium. Our findings are consistent with the possibility that excessive, dysregulated extravasation of T cells induced by irradiation promotes the development of GVHD.
机译：移植前的调理方案在引发移植物抗宿主病（GVHD）中起主要作用。这项研究通过比较羧基荧光素双乙酸酯琥珀酰亚胺酯标记的天然供体T淋巴细胞在受辐照和未辐照的同系小鼠体内的迁移，研究了辐照对供体T细胞向淋巴和非淋巴组织运输的影响。 。在辐照小鼠中，过继转移的幼稚T细胞对次要淋巴器官的募集增加，幼稚T细胞也异常地定位于非淋巴组织。辐照还会诱导效应记忆T细胞异常迁移到淋巴结中，并定位到归巢特权的非淋巴部位，例如肠道。较小的组织相容性错配的存在进一步增强了T细胞在淋巴组织和非淋巴组织中的异常积累，而与完全匹配的受辐照者相比，它们的迁移方式没有改变。这些作用与内皮的通透性降低和趋化因子的分泌有关。我们的发现与辐射诱导的T细胞过度，失调的外渗促进GVHD发生的可能性是一致的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号